… Endothelin-1's actions are primarily local, in a paracrine (ET-… be a target of NK1 receptors,
activated by Substance P, but in … the rat sciatic nerve, with a substantial contribution from local …

… , associated innervation, increased substance P (SP) and … fibers lead to activation of MCs
via SP action on NK1 receptors. … We observed that MC activation is increased in sickle mice …

… or paracrine actions on a family of prostaglandin receptors on the … There are also results
from studies in mice deficient in the … and substance P in the spinal cord leading to activation of …

… rat trigeminal ganglion (TG) neurons and whether the inhibition of the transient K + current (I
A ) contributed to … the facial skin via a paracrine mechanism due to the release of substance …

… neurons contribute to the mechanism of hyperalgesia and/or referred … trigeminal root
ganglion neurons and this effect is associated with the inhibition of the hyperpolarization-activated …

… These mice exhibit increased NMDA receptor activation in … of NK1 receptor-positive lamina
I neurons using substance P-… A recent study in the rat trigeminal nucleus caudalis found no …

… Through these interactions and paracrine communication … this effect is potentiated by
substance P. In normal conditions, … A study in mice showed that peripheral inflammation activated …

… corneal–trigeminal axis, where substance P orchestrates the … mu-opiate receptors in trigeminal
ganglion in control mice and … inhibition of neurokinin 1 receptor utilizing fosaprepitant is …

… have been induced in rats or mice using complete Freund's … trials of neurokinin-1 receptor
or purinergic receptor antagonists, … to release of neuropeptides, such as substance P and …

… , morphologically specialized sensory receptors are activated to generate receptor potential,
… Whether substance P contributes to abnormal pain is unclear. Studies in these null mice …