The role of the neuronal microenvironment in sensory function and pain pathophysiology
H Starobova, A Alshammari, IG Winkler… - Journal of …, 2022 - Wiley Online Library
… Cre- DTA mice leads to an increased number of neutrophils, and … Substance P released by
neurons activates Mas- related G- … Neurokinin- 1 receptor agonists bias therapeutic dendritic …
neurons activates Mas- related G- … Neurokinin- 1 receptor agonists bias therapeutic dendritic …
Inhibitory Gi/O-coupled receptors in somatosensory neurons: Potential therapeutic targets for novel analgesics
… Substance P activates Neurokinin receptors (NK1–3), which … SST reduced mechanical
allodynia in a rat inflammatory pain … and acts as a paracrine signal; it activates both metabotropic (…
allodynia in a rat inflammatory pain … and acts as a paracrine signal; it activates both metabotropic (…
Peripheral and Central Inflammation Caused by Neurogenic and Immune Systems and Anti-Inflammatory Drugs
A Hiura, H Nakagawa, E Kumamoto… - Frontiers in Clinical Drug …, 2016 - books.google.com
… Neuropeptide mediators such as substance P (SP) or … thermal hyperalgesia and mechanical
allodynia in CCI rats by intra-… of rat spinal cord slices; at C-fiber synapses in NK1 receptor-…
allodynia in CCI rats by intra-… of rat spinal cord slices; at C-fiber synapses in NK1 receptor-…
Nerve growth factor alters the sensitivity of rat masseter muscle mechanoreceptors to NMDA receptor activation
H Wong, XD Dong, BE Cairns - Journal of Neurophysiology, 2014 - journals.physiology.org
… recordings of trigeminal ganglion neurons innervating the … during injury via facilitation of the
release of glutamate and substance P (… This central mechanism may contribute more to NGF-…
release of glutamate and substance P (… This central mechanism may contribute more to NGF-…
The role of peptides in central sensitization
VS Seybold - Sensory Nerves, 2009 - Springer
… Using substance P (SP) and calcitonin gene-related peptide (… In addition to autocrine
regulation, the possibility of paracrine … NK1 receptor mRNA in dorsal root ganglia of naïve rats or …
regulation, the possibility of paracrine … NK1 receptor mRNA in dorsal root ganglia of naïve rats or …
Diagnosis, pathophysiology, management and future issues of trigeminal surgical nerve injuries
T Renton, F Van der Cruyssen - Oral Surgery, 2020 - Wiley Online Library
… The NK1 receptors are also present in the glial cells. … Paracrine effects cause simultaneous
release of IL-1 β that in turn … ◦ A decrease in substance P immunoreactivity at 60 days after …
release of IL-1 β that in turn … ◦ A decrease in substance P immunoreactivity at 60 days after …
Does inflammation have a role in migraine?
L Edvinsson, KA Haanes, K Warfvinge - Nature Reviews Neurology, 2019 - nature.com
… Furthermore, substance P receptor antagonists have failed in … CFA into the temporomandibular
joint (TMJ) (Fig. 3) elicited … ) immunoreactivity in the rat trigeminal ganglion before and 2 …
joint (TMJ) (Fig. 3) elicited … ) immunoreactivity in the rat trigeminal ganglion before and 2 …
Adenovector GAD65 gene delivery into the rat trigeminal ganglion produces orofacial analgesia
…, P Maechler, C Liu, M Puntel, P Lowenstein… - … pain, 2009 - journals.sagepub.com
… Injection of adenoviral vectors (AdGAD65) directly into the trigeminal ganglion leads …
substance P could act in a paracrine manner in sensory ganglia to activate neurokinin-1 receptors …
substance P could act in a paracrine manner in sensory ganglia to activate neurokinin-1 receptors …
Effect of resveratrol on the hyperexcitability of nociceptive neurons associated with ectopic hyperalgesia induced by experimental tooth movement
N Okubo, H Ishikawa, R Sano… - European Journal of …, 2020 - Wiley Online Library
… reported that temporomandibular joint inflammation modulates … a Substance P/neurokinin-1
receptor paracrine signaling … remote from the inflamed area in rats exposed to experimental …
receptor paracrine signaling … remote from the inflamed area in rats exposed to experimental …
Intervertebral disc herniation, spinal nociceptive signaling and proinflammatory mediators
DP Jacobsen - 2014 - duo.uio.no
… the dorsal nerve roots of female Lewis rats induced a significant … , ie proteins, performing
paracrine, autocrine and endocrine … contributes to tactile hypersensitivity following trigeminal …
paracrine, autocrine and endocrine … contributes to tactile hypersensitivity following trigeminal …