Synopsis on managment strategies for neurodegenerative disorders: Challenges from bench to bedside in successful drug discovery and development

S Ahmad Bhat, M Amjad Kamal… - Current topics in …, 2017 - ingentaconnect.com
… dismutase 1 and sporadic amyotrophic lateral sclerosis: analysis of 155 … in a sporadic
amyotrophic lateral sclerosis patient. Mol. Cell. … Amyotrophic lateral sclerosis in an urban setting: a …

Amyotrophic lateral sclerosis: from current developments in the laboratory to clinical implications

M Cozzolino, A Ferri, M Teresa Carri - Antioxidants & redox …, 2008 - liebertpub.com
… The clinical implication of these findings is that promising therapeutic approaches can be
derived from multidrug treatments aimed at the simultaneous interception of damage in both …

Amyotrophic lateral sclerosis: clinical management and research update

J Andrews - Current neurology and neuroscience reports, 2009 - Springer
… of a variety of medical experts in related fields. … therapy Riluzole is an antagonist to glutamate
release and is the only disease-modifying drug approved for ALS by the US Food and Drug

From bench to FDA to bedside: US regulatory trends for new stem cell therapies

PS Knoepfler - Advanced drug delivery reviews, 2015 - Elsevier
Multiple Sclerosis (MS) or Amyotrophic Lateral Sclerosis (ALS). In this instance, adipose
tissue has no homology to the diseased tissues, and the logic then is that non-homologous use …

From the laboratory bench to the patient's bedside: an update on clinical trials with mesenchymal stem cells

A Giordano, U Galderisi… - Journal of cellular …, 2007 - Wiley Online Library
… We describe progress for neurological disease treatment with MSC transplants. We
discuss data on amyotrophic lateral sclerosis (ALS) and on lysosomal storage diseases (Hurler …

Advances in patient-specific induced pluripotent stem cells shed light on drug discovery for amyotrophic lateral sclerosis

JH Lee, JW Liu, SZ Lin, HJ Harn… - Cell …, 2018 - journals.sagepub.com
… Neurological diseases such as amyotrophic lateral sclerosis (… of new drugs and/or drug
screening for ALS treatment and … a potential therapeutic target in amyotrophic lateral sclerosis. …

A promising new therapy for ALS

H Wood - Nature reviews. Neurology, 2021 - search.proquest.com
drug AmX0035 has beneficial effects on survival and function in people with amyotrophic
lateral sclerosis (… The two drugs individually exhibit neuroprotective properties in experimental …

Organ on a Chip: A Novel in vitro Biomimetic Strategy in Amyotrophic Lateral Sclerosis (ALS) Modeling

B Arjmand, S Kokabi Hamidpour, Z Rabbani… - Frontiers in …, 2022 - frontiersin.org
treatment has been found for amyotrophic lateral sclerosis (… the disease, multiple medical
therapies have been proposed … translational researches from bench to bedside in various …

TDP-43 and Neurodegeneration: From Bench to Bedside

V Kumar, MK Jaiswal - 2021 - books.google.com
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are common
neurodegenerative disorders that are relentlessly progressive, fatal, and without effective treatment, …

Silence superoxide dismutase 1 (SOD1): a promising therapeutic target for amyotrophic lateral sclerosis (ALS)

E Abati, N Bresolin, G Comi, S Corti - Expert opinion on therapeutic …, 2020 - Taylor & Francis
… the small study sample and the low treatment doses received by patients. Another silencing
… RNAi therapy from the bench to the bedside is the lack of an in vivo biomarker of therapeutic