Gene therapy of the central nervous system: from bench to bedside

MG Kaplitt, M During - 2006 - books.google.com
… Transduction of glia may be desirable for development of gene therapy-based treatments
for demyelinating diseases such as multiple sclerosis and Canavan disease. Under certain …

[HTML][HTML] Mesenchymal stem cell therapy in amyotrophic lateral sclerosis (ALS) patients: A comprehensive review of disease information and future perspectives

S Najafi, P Najafi, NK Farkhad, GH Torshizi… - … of Basic Medical …, 2023 - ncbi.nlm.nih.gov
Amyotrophic lateral sclerosis (… drug for the management of this disease, there is still no
definitive cure for it. In this regard, the use of mesenchymal stem cells (MSCs) for the treatment or …

Advancing stem cell therapy from bench to bedside: lessons from drug therapies

TC Srijaya, TS Ramasamy, NHA Kasim - Journal of translational medicine, 2014 - Springer
… Currently, phase I clinical trial is being conducted on dose escalation study of autologous
MSCs in patients with Amyotrophic Lateral Sclerosis for determining the dose limiting toxicities […

miRNAs: The road from bench to bedside

G Iacomino - Genes, 2023 - mdpi.com
bench to the patient’s bedside, working on two types of drugs: antagomiRs and miRNA mimics.
The list of miRNA-based drugs in … processes in amyotrophic lateral sclerosis (ALS). In the …

Cellular transplants in amyotrophic lateral sclerosis patients: an observational study

J Gamez, F Carmona, N Raguer, J Ferrer-Sancho… - Cytotherapy, 2010 - Elsevier
… neurodegenerative disease treatment. Because of the fatal prognosis and imperative need
for effective treatment, amyotrophic lateral sclerosis (ALS) patients request this therapy before …

Therapeutic opportunities and challenges of induced pluripotent stem cells-derived motor neurons for treatment of amyotrophic lateral sclerosis and motor neuron …

MK Jaiswal - Neural regeneration research, 2017 - journals.lww.com
drug from the bench to bedside is very expensive, laborious and slow process. The cost of
development and validation of potential therapeutic … with consecutive drug therapies until the …

[HTML][HTML] Spinal muscular atrophy: journeying from bench to bedside

T Awano, JK Kim, UR Monani - Neurotherapeutics, 2014 - Elsevier
… -type drugs will likely constitute the next generation of therapeutic agents for the treatment
of … common motor neuron disease, amyotrophic lateral sclerosis has already been reported […

Amyotrophic lateral sclerosis: update and new developments

AJ Pratt, ED Getzoff, JJP Perry - Degenerative neurological and …, 2012 - Taylor & Francis
Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease. It is
typically characterized by adult-onset degeneration of the upper and lower motor neurons, …

Targeting the Neuromuscular Junction in ALS

J Wymer, DR Borchelt - Neurotherapeutics, 2018 - Springer
… basis for amyotrophic lateral sclerosis (ALS) has grown enormously. From these studies, it is
clear that defects in multiple … This example of bench to bedside drug development is a clear …

The bench is closer to the bedside than we think: Uncovering the ethical ties between preclinical researchers in translational neuroscience and patients in clinical …

M Yarborough, A Bredenoord, F D'Abramo… - PLoS …, 2018 - journals.plos.org
… States Food and Drug Administration (FDA) for treatment of amyotrophic lateral sclerosis (ALS), …
Is the Subject Area "Amyotrophic lateral sclerosis" applicable to this article? Yes No …