… antagonist antibodies in combination with a cellular vaccine were capable of inducing regression
of … constructs or anti-CD2 mimic the adverse effect profile of alefacept seen in humans. …

… Monoclonal antibodies (MAb) have been shown to be effective in inducing immune … The
same MAb have also been shown to prevent the onset of experimental autoimmune arthritis as …

… experimental animal models by biologic agents. Two new therapeutic avenues—gene therapy
and the induction of … Anti-CD2 monoclonal antibodies prevent spontaneous and adoptive …

… Furthermore experimental animal models have shown that depletion of T cells prevents
the induction of autoimmune myocarditis [10]. Based on these experimental models, and our …

… may protect against various solid and haematological cancers. Several monoclonal antibodies
(mAbs) that block … , targeting these pathways have the potential to induce irAEs, which are …

… fibrosis in murine experimental autoimmune myocarditis (in … The same was true of mice
given anti-CD2 antibody which … -specific IgG monoclonal antibody induced mild myocarditis in …

… this, researchers used agonistic monoclonal antibodies directed at … The clinical benefits of
anti-CD2 mAb could be seen in … can result in autoimmune cardiomyopathy, consistent with its …

… phocyte staining anti-CD2, -CD3 (Dakopatts) antibodies were … (FCS) to block nonspecific
immunoglobulin binding. Specific … and specificity, monoclonal antibodies directed against T-cell …

… with anti- CD2 (A, B), CD4 (C, D), and CD8 (E, F) antibodies, … transplantation with mouse
monoclonal antibody against an … ameliorates ongoing experimental autoimmune myocarditis. …

… first-degree AV block, right bundle-branch block and left anterior hemiblock… induction with
anti-thymocyte gammaglobulin (ATGAM), 10 mg/kg/day for 5 days (equine polyclonal antibody …