Protein folding and aggregation into amyloid: the interference by natural phenolic compounds

M Stefani, S Rigacci - International journal of molecular sciences, 2013 - mdpi.com
… to cell membrane permeability, mitochondria functioning, ER … powerful agent preventing
β-amyloid deposition-associated … of resveratrol protection is multifaceted; besides its antioxidant

Screening for amyloid-β aggregation inhibitor and neuronal toxicity of eight Tunisian medicinal plants

Z Dhouafli, S Rigacci, M Leri, M Bucciantini… - Industrial crops and …, 2018 - Elsevier
… The aggregation and deposition of misfolded β-amyloid … In this test, we measured the relative
ability of antioxidants to … in Ca 2+ signaling pathway in order to protect cells from the toxicity …

Narrative Review: Edible Plants as a Source of Valuable Flavonoids and Their Role as Neuroprotector Agents

RMP Gutiez - Current Nutrition & Food Science, 2023 - ingentaconnect.com
… and cellular events such as impaired mitochondrial function, … Apigenin attenuates
coppermediated β-amyloid … and MAPK signal inactivation in an AD cell model. Brain Res 2013; …

[PDF][PDF] Flavonoids and their Therapeutic Applications in Neurological Disorders

K Manocha, N Bharadvaja - afjbs.com
… disorders through their anti-inflammatory, antioxidant, and … stress, neuroinflammation, and
mitochondrial dysfunction all of … Several key molecular signaling pathways such as MAPK, …

Linlin Wang1, 2†, Jiansong Fang3†, Hailun Jiang1, Qian Wang1, Situ Xue1, Zhuorong Li1* and Rui Liu1

C Mancuso - Alzheimer's Disease: Original Mechanisms and …, 2020 - books.google.com
… ) signaling transduction are due to β-amyloid (Aβ)-stimuli via a … to LC1405 neuroprotection
against copper-mediated Aβ toxicity. … attenuates β-amyloidinduced toxicity through anti-…

Potential involvement of oxidative stress in induction of neurodegenerative diseases: Actions, mechanisms and neurotherapeutic potential of natural antioxidants

GLS Oliveira, FRAM Oliveira, RM Freitas - 2014 - repositorio.ufc.br
… s disease-related CuII-β-amyloid complexes-cooperative action … attenuated MPP+-induced
cytotoxicity by anti-oxidation and … and MAPK signal inactivation in an AD cell model. Brain Res…

Neuroprotective Effects of Hydroalcoholic Extract of Ocimum sanctum Against H2O2 Induced Neuronal Cell Damage in SH-SY5Y Cells via Its Antioxidative Defence …

MP Venuprasad, K Hemanth Kumar, F Khanum - Neurochemical research, 2013 - Springer
… we have evaluated the protective effect of OSE … of apigenin one of the major constituent
of Ocimum, which ameliorates Alzheimer’s symptoms via regulation of ROS and mitochondrial

[HTML][HTML] Nutraceuticals in cognitive impairment and Alzheimer's disease

P Mecocci, C Tinarelli - Frontiers in pharmacology, 2014 - frontiersin.org
protective effect of catechins in cellular and animal models of … with luteolin and apigenin in
cognitive impairment or AD. … or antioxidant mixtures also display little benefit against AD onset …

Reducing PDK1/Akt activity: an effective therapeutic target in the treatment of Alzheimer's disease

S Yang, Y Du, X Zhao, C Wu, P Yu - Cells, 2022 - mdpi.com
… Akt also regulates the phosphorylation and inactivation of … In AD, the activation of MAPK
is remarkedly associated with … and mitochondrial stress through activation of MAPK in the …

Neuroprotective agents with therapeutic potential for COVID-19

CA Zaa, C Espitia, KL Reyes-Barrera, Z An… - Biomolecules, 2023 - mdpi.com
… and/or cellular damage by altering the mitochondrial oxidative … Furthermore, apigenin
attenuates microglial activation and … molecules of natural origin with antioxidant, anti-inflammatory …