Determinants of prescription and choice of empirical therapy for hospital-acquired and ventilator-associated pneumonia

J Rello, M Ulldemolins, T Lisboa… - European respiratory …, 2011 - Eur Respiratory Soc
Appropriate empirical antibiotics decreased ICU length of stay by 6 days (26.3±19.8 days
versus 32.8±29.4 days; p = 0.04). The antibiotics … rather than focusing on risk factors for specific …

Mortality in patients with septic shock by multidrug resistant bacteria: risk factors and impact of sepsis treatments

S Busani, G Serafini, E Mantovani… - Journal of intensive …, 2019 - journals.sagepub.com
adult patients with septic shock caused by MDR infections admitted to our intensive care unit
(ICU) … However, in our cohort, the appropriateness of initial empirical antibiotic therapy was …

[HTML][HTML] Failure of target attainment of beta-lactam antibiotics in critically ill patients and associated risk factors: a two-center prospective study (EXPAT)

A Abdulla, A Dijkstra, NGM Hunfeld, H Endeman… - Critical Care, 2020 - Springer
… Early and appropriate antibiotic dosing is associated with improved clinical outcomes in …
in two ICUs in the Netherlands. We enrolled adult patients treated with the following beta-lactam …

Multidrug-resistant bacteria on critically ill patients with sepsis at hospital admission: Risk factors and effects on hospital mortality

MO Maia, CDG da Silveira, M Gomes… - Infection and Drug …, 2023 - Taylor & Francis
… seven adult patients with sepsis were admitted to the ICU within … appropriateness of the
initial antibiotic therapy. According to our institutional protocol, adult patients with sepsis or septic

Factors associated with suitability of empiric antibiotic therapy in hospitalized patients with bloodstream infections

C Grossman, N Keller, G Bornstein… - Journal of …, 2017 - Taylor & Francis
… The main risk factor for inappropriate initial empiric antibiotic therapy was healthcare-…
Therefore, it may not be applicable to patients hospitalized in intensive care units or surgery …

29 What Is the Role of Empirical Antibiotic Therapy in Sepsis?

PS Barie, SR Eachempati - … -Based Practice of Critical Care E …, 2010 - books.google.com
Risk factors for antibiotic-resistant infection in the case of health care–… Initial antibiotic
therapy was appropriate for 55 patients (49.5%). ICU length of stay was shorter with appropriate

[HTML][HTML] Risk factors of initial inappropriate antibiotic therapy and the impacts on outcomes of neonates with gram-negative bacteremia

SM Chu, JF Hsu, MY Lai, HR Huang, MC Chiang… - Antibiotics, 2020 - mdpi.com
… : Timely appropriate empirical antibiotic plays an important role in critically ill patients with
gram-… onset of gram-negative sepsis from neonates in the neonatal intensive care unit (NICU). …

Antibiotic strategies in severe nosocomial sepsis: why do we not de-escalate more often?

S Heenen, F Jacobs, JL Vincent - Critical care medicine, 2012 - journals.lww.com
… The choice of empirical antibiotic therapy … appropriate empirical antimicrobial treatment
may be improved by using a wider-spectrum microbiological policy at the beginning of the septic

[HTML][HTML] Antibiotic prescription patterns in the empiric therapy of severe sepsis: combination of antimicrobials with different mechanisms of action reduces mortality

A Díaz-Martín, ML Martínez-González, R Ferrer… - Critical care, 2012 - Springer
Appropriate empiric antimicrobial therapy is crucial for the survival of sepsis patients [4, 5].
Formerly, multidrug-resistant pathogens were found almost exclusively in nosocomial …

Systematic review of the impact of appropriate versus inappropriate initial antibiotic therapy on outcomes of patients with severe bacterial infections

M Bassetti, J Rello, F Blasi, H Goossens… - International journal of …, 2020 - Elsevier
… that reported patient mortality during ICU or … patients, early initiation of effective broad-spectrum
empirical therapy may be preferable but should be based on analysis of local risk factors