[HTML][HTML] Prospective validation of VEGF and eNOS polymorphisms as predictors of first-line bevacizumab efficacy in patients with metastatic colorectal cancer

G Marisi, I Azzali, A Passardi, F Rebuzzi, G Bartolini… - Scientific Reports, 2023 - nature.com
… The primary objective of the study was to assess the correlation of the selected polymorphisms
with PFS. Secondary objectives were the correlations with OS and ORR. The Local Ethics …

Bevacizumab and first-line chemotherapy for older patients with advanced colorectal cancer: final results of a community-based observational Italian study

SE Lutrino, F Bergamo, M Schirripa, G Rosati… - Anticancer …, 2015 - ar.iiarjournals.org
… showed that the correlation between the vascular side-effect and the clinical outcome was
uncertain, since the development of bevacizumab-induced hypertension was inconsistently …

Vascular endothelial growth factor polymorphisms and clinical outcome in colorectal cancer patients treated with irinotecan-based chemotherapy and bevacizumab

AK Koutras, AG Antonacopoulou… - The …, 2012 - nature.com
… with bevacizumab, as first-line treatment for metastatic colorectalArterial hypertension
correlates with clinical outcome in colorectal cancer patients treated with first-line bevacizumab

Evaluation of hypertension as a marker of bevacizumab efficacy

R Ryanne Wu, PA Lindenberg, R Slack… - … gastrointestinal cancer, 2009 - Springer
… with clinical outcome in metastatic colorectal cancer patients … at diagnosis had bevacizumab
as part of first-line therapy. … support looking further into this correlation with the creation of a …

[HTML][HTML] … VEGF-a and ACE plasma levels of metastatic colorectal cancer patients have prognostic value for first-line treatment with chemotherapy plus bevacizumab

MJ Ortiz-Morales, M Toledano-Fonseca… - Cancers, 2022 - mdpi.com
… -EGFR; no indication for bevacizumab due to uncontrolled arterial hypertension and/or …
correlation between plasma VEGF-A and outcomes in mCRC patients treated with bevacizumab

Bevacizumab-based therapies in the first-line treatment of metastatic colorectal cancer

JH Strickler, HI Hurwitz - The oncologist, 2012 - academic.oup.com
… for the first-line treatment of metastatic colorectal cancer (mCRC), bevacizumab has become
a standard treatment option in combination with chemotherapy for patients with mCRC. …

[HTML][HTML] Efficacy of bevacizumab and chemotherapy in the first-line treatment of metastatic colorectal cancer: broadening KRAS-focused clinical view

B Bencsikova, Z Bortlicek, J Halamkova… - BMC …, 2015 - Springer
… with bev plus oxaliplatin- or irinotecan-based chemotherapy, and correlated treatment
outcomes with KRAS mutation status. The primary endpoint was progression-free survival (PFS) …

[HTML][HTML] eNOS polymorphisms as predictors of efficacy of bevacizumab-based chemotherapy in metastatic colorectal cancer: data from a randomized clinical trial

P Ulivi, E Scarpi, A Passardi, G Marisi, D Calistri… - Journal of translational …, 2015 - Springer
Bevacizumab plus chemotherapy is a widely used therapeutic option for first-line treatment of
metastatic colorectal cancer … most strongly correlated with response to bevacizumab. It also …

Risk/benefit profile of bevacizumab in metastatic colon cancer: a systematic review and meta-analysis

E Galfrascoli, S Piva, M Cinquini, A Rossi… - Digestive and Liver …, 2011 - Elsevier
… of bevacizumab-related side effects in patients affected by advanced colorectal cancer and
… concluded that elderly patients receiving bevacizumab with first-line chemotherapy showed …

[HTML][HTML] Cardiovascular complications of metastatic colorectal cancer treatment

K Keramida, G Charalampopoulos… - … Oncology, 2019 - ncbi.nlm.nih.gov
… During first-line treatment, 90% of patients … ), pulmonary embolism (PE) and thrombophlebitis.
However, the added risk of bevacizumab to VTEs is ambiguous, since cancer patients are …