Pharmacogenetic angiogenesis profiling for first-line Bevacizumab plus oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer

A Gerger, A El-Khoueiry, W Zhang, D Yang… - Clinical Cancer …, 2011 - AACR
cancer (mCRC) patients treated with bevacizumab and oxaliplatin-based chemotherapy.
Experimental Design: A total of 132 patients treated with first-line bevacizumab and … correlates. …

[PDF][PDF] Bevacizumab (bev) in combination with capecitabine (cape) for the first-line treatment of elderly patients with metastatic colorectal cancer (mCRC): results of a …

D Cunningham, I Lang, V Lorusso… - J. Clin …, 2013 - hematologyandoncology.net
Clinical outcomes in elderly patients with metastatic colorectal cancer receiving bevacizumab
… rash, have been correlated with improved outcomes in patients with non–small cell lung …

Doubling the dose of bevacizumab beyond progression in metastatic colorectal cancer–the experience of a tertiary cancer center

C Căinap, OV Bochiş, C Vlad, R Popita… - Frontiers in …, 2021 - frontiersin.org
… CRC patients treated between 2009 and 2017 outside of a clinicalpatients who used
bevacizumab as first-line and second-line … and negatively correlated with delayed bevacizumab

Impact of pre-angiogenic factors on the treatment effect of bevacizumab in patients with metastatic colorectal cancer

A Dirican, Y Kucukzeybek, A Alacacioglu, U Varol… - Medical Oncology, 2014 - Springer
… CA 19-9 levels with the clinical outcome of mCRC patients treated with first-line
bevacizumab-based … ET-1 levels were strongly correlated with the clinical outcome of mCRC …

Hypertension as a surrogate marker for the activity of anti-VEGF agents

O Mir, S Ropert, J Alexandre… - … of oncology, 2009 - annalsofoncology.org
Arterial hypertension correlates with clinical outcome in colorectal cancer patients treated
with first-line bevacizumab. … in colorectal cancer patients treated with first-line bevacizumab. …

Analysis of adverse events of bevacizumab-containing systemic chemotherapy for metastatic colorectal cancer in Japan

T Isobe, K Uchino, C Makiyama, H Ariyama… - Anticancer …, 2014 - ar.iiarjournals.org
… , clinical trials (5-7). Based on these results, BV was approved for the first-line and second-line
treatment of … , and no correlation was observed between remaining primary tumors and …

Bevacizumab with FOLFOXIRI (irinotecan, oxaliplatin, fluorouracil, and folinate) as first-line treatment for metastatic colorectal cancer: a phase 2 trial

G Masi, F Loupakis, L Salvatore, L Fornaro… - … lancet oncology, 2010 - thelancet.com
… phase 3 trial in patients with metastatic colorectal cancer. Results of … of bevacizumab to
chemotherapy increases treatment efficacy. … plus bevacizumab in patients with colorectal cancer. …

Bevacizumab, a humanized anti‐angiogenic monoclonal antibody for the treatment of colorectal cancer

I Krämer, HP Lipp - … of clinical pharmacy and therapeutics, 2007 - Wiley Online Library
… VEGF is expressed in a wide variety of tumour types and tumour VEGF levels often correlate
… In a pivotal phase III trial of first-line bevacizumab (5 mg/kg every 2 weeks) in combination …

Bevacizumab-induced hypertension: pathogenesis and management

KN Syrigos, E Karapanagiotou, P Boura, C Manegold… - BioDrugs, 2011 - Springer
… antibody targeting the vascular endothelial growth factor (… -line treatment of colorectal
cancer and in the first-line treatment of … has been correlated with worse clinical outcome.[11,12,13] …

… bevacizumab as second-line therapy for patients with metastatic colorectal cancer that progressed on bevacizumab with chemotherapy: the Gunma Clinical Oncology …

S Tsutsumi, K Ishibashi, N Uchida, H Ojima… - Oncology, 2012 - karger.com
… Although it has been reported that there is a correlation between exposure to 3 highly … in
patients with metastatic colorectal cancer receiving first-line chemotherapy plus bevacizumab: a …