Assessment of solid microneedle rollers to enhance transmembrane delivery of doxycycline and inhibition of MMP activity

A Omolu, M Bailly, RM Day - Drug delivery, 2017 - Taylor & Francis
… of an epidermal mimetic with microneedle rollers provides sufficient permeabilization for
doxycycline diffusion and inhibition of MMP activity. We conclude that microneedle rollers are a …

Microneedles-based transdermal drug delivery systems: a review

Y Hao, W Li, XL Zhou, F Yang… - Journal of biomedical …, 2017 - ingentaconnect.com
… The solid microneedle roller enhanced the transmembrane delivery of doxycycline and
inhibition of MMP activity.Kalluri … could be an attractive application in blood analysis systems.The …

[HTML][HTML] Physical drug delivery enhancement for aged skin, UV damaged skin and skin cancer: Translation and commercialization

M Yamada, TW Prow - Advanced drug delivery reviews, 2020 - Elsevier
Delivery was assessed in thawed porcine skin from the … show that microneedles can enhance
the delivery of small … enhancement may have been inhibited by the hydrophobic properties …

Microneedles as an alternative technology for transdermal drug delivery systems: a patent review

MLB Queiroz, S Shanmugam, LNS Santos… - Expert opinion on …, 2020 - Taylor & Francis
… bioactives and enhance transdermal and dermal delivery. So… the uniformity control membrane
is substantially greater than … from the skin for analysis such as analysis of blood sugar for …

[HTML][HTML] Going below and beyond the surface: Microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration

S Lyu, Z Dong, X Xu, HP Bei, HY Yuen, CWJ Cheung… - Bioactive Materials, 2023 - Elsevier
… could pass through the cell membrane easily, making it an … of many enzymes, like matrix
metalloproteinase, human neutrophil … wounds, microneedles are necessary to improve the drug …

Breast Tissue as a Local Drug Reservoir for Anticancer Therapy in Breast Cancer

S Shchinar - 2024 - openprairie.sdstate.edu
… by the milk duct basement membrane, coupled with the distance … enhance the delivery of
drug molecules. Techniques such as … , and assess a local transdermal drug delivery system of …

Microneedle arrays for the treatment of chronic wounds

L Barnum, M Samandari, TA Schmidt… - … on drug delivery, 2020 - Taylor & Francis
… layers of skin for enhanced delivery of therapeutics [Citation86] … The PCL nanoparticles
were loaded with Doxycycline, an … ISF and removing it for secondary analysis [Citation87]. This …

[PDF][PDF] A REVIEW PAPER ON POLYMERIC MICRONEEDLE FOR TRANSDERMAL DRUG DELIVERY

A Dahiya, R Kaur - 2021 - researchgate.net
… Omolu, A., Bailly, M., Day, RM, Assessment of solid microneedle rollers to enhance trans
membrane delivery of doxycycline and inhibition of MMP activity. Drug Deliv., 2017; 24(1): 942–…

Dissolving microneedle rollers for rapid transdermal drug delivery

XP Zhang, BL Zhang, BZ Chen, ZQ Zhao… - Drug Delivery and …, 2022 - Springer
… of a cylinder roller and fabricated by metallic or solid materials [… assess and compare the in
vivo insertion and drug delivery … to expand the application of DMN to enable delivering drugs …

[HTML][HTML] Microneedles for enhanced topical treatment of skin disorders: applications, challenges, and prospects

T Peng, Y Chen, W Hu, Y Huang, M Zhang, C Lu… - Engineering, 2023 - Elsevier
… The qualitative and quantitative evaluation of MNs can help … membrane-inspired biomineralized
NPs that were delivered … responses and exerted a better tumor inhibitory effect. The DNA …