Establishment of type 2 diabetes mellitus models using streptozotocin after 3 months high-fat diet in Bama minipigs

Y Zhao, M Niu, Y Jia, J Yuan, L Xiang, X Dai… - Animal …, 2023 - Taylor & Francis
… fed a high-fat or high-cholesterol/high-fat diet and injected with … et al. induced type 1 diabetes
in Yucatan miniature pigs with … not induce accelerated atherosclerosis during the 9-month …

[HTML][HTML] Application of the transgenic pig model in biomedical research: a review

J Wei, W Zhang, J Li, Y Jin, Z Qiu - Frontiers in Cell and …, 2022 - frontiersin.org
… GGTA1-knockout Yucatan miniature pig model in this study can … One case of transgenic
Wuzhishan mini pigs was produced by … pigs reproduced the human-like atherosclerotic lesions …

Antiatherosclerotic activity of eriocitrin in high-fat-diet-induced atherosclerosis model rats

J Wan, Y Feng, L Du, VP Veeraraghavan… - Journal of …, 2020 - dl.begellhouse.com
… beneficial lipid-lowering action in rats subjected to high fat diet. The anti-atherosclerotic
efficacy of eriocitrin was assessed in rats administered a diet rich in fat. Wistar rats were divided …

Effect of testosterone deficiency on cholesterol metabolism in pigs fed a high-fat and high-cholesterol diet

Z Cai, H Xi, Y Pan, X Jiang, L Chen, Y Cai… - Lipids in health and …, 2015 - Springer
… Eighteen sexually mature male Chinese Wuzhishan (WZS) miniature pigs (6–7 months
old) … , which has been shown to induce hypercholesterolemia and atherosclerosis in pigs [18],[19]…

[HTML][HTML] Cinnamaldehyde Mitigates Atherosclerosis Induced by High-Fat Diet via Modulation of Hyperlipidemia, Oxidative Stress, and Inflammation

BS Ismail, B Mahmoud, ES Abdel-Reheim… - … Medicine and Cellular …, 2022 - hindawi.com
… effect of Ci against atherosclerosis induced by a high-fat diet (HFD) in Wistar rats. … induced
by a high-cholesterol and high-fat diet in the inbred strain of the Wuzhishan miniature pig,” …

MX1 and UBE2L6 are potential metaflammation gene targets in both diabetes and atherosclerosis

G Wang, R Hua, X Chen, X He, Y Dingming, H Chen… - PeerJ, 2024 - peerj.com
… In the experiment involving pig models with a high-cholesterol, high-fat diet and STZ
injection, MX1 and UBE2L6 were successfully screened out as much as possible to reduce the …

Porcine models for studying complications and organ crosstalk in diabetes mellitus

S Renner, A Blutke, S Clauss, CA Deeg, E Kemter… - Cell and tissue …, 2020 - Springer
… activity, Chinese Bama miniature pigs exhibited a higher … high-fat-high-cholesterol (HFHC)
diet. After 46 weeks on the HFHC … atherosclerosis in PCSK9 D374Y transgenic Ossabaw pigs

Identification of Body Size Determination Related Candidate Genes in Domestic Pig Using Genome-Wide Selection Signal Analysis

B Pan, H Long, Y Yuan, H Zhang, Y Peng, D Zhou… - Animals, 2022 - mdpi.com
… Other breeds, such as Bama Xiang and Wuzhishan pigs, are … ], reproductive toxicity [13],
atherosclerosis [14,15], diabetes [… highly selective regions in miniature pigs to identify CGs that …

Integrated analysis of DNA methylome and transcriptome reveals the differences in biological characteristics of porcine mesenchymal stem cells

Z Feng, Y Yang, Z Liu, W Zhao, L Huang, T Wu… - BMC Genomic Data, 2021 - Springer
… were isolated from inbred Wuzhishan miniature pigs and the first … shows high genetic stability
[14], and its inbreeding … human diseases, including atherosclerosis, cardiovascular disease…

Site-specific atherogenic gene expression correlates with subsequent variable lesion development in coronary and peripheral vasculature

ER Mohler III, L Sarov-Blat, Y Shi… - Arteriosclerosis …, 2008 - Am Heart Assoc
… Also unclear is whether development of atherosclerosis in … We tested this hypothesis in
the atherosclerotic DM/HC swine … markers and the high-fat diet associations between several …