Immunisation with Recombinant PfEMP1 Domains Elicits Functional Rosette-Inhibiting and Phagocytosis-Inducing Antibodies to Plasmodium falciparum

A Ghumra, P Khunrae, R Ataide, A Raza, SJ Rogerson… - PloS one, 2011 - journals.plos.org
… IgG preparations to recognize live infected erythrocytes, we … Although var2CSA is the most
promising current PfEMP1 … -His antibody (Qiagen, Crawley, UK), showed that all constructs

Can any lessons be learned from the ambiguous glycan binding of PfEMP1 domains?

M Dahlbäck, MA Nielsen, A Salanti - Trends in parasitology, 2010 - cell.com
… (PAM) is caused by Plasmodium falciparum-infected erythrocytes (IEs) … The multi-domain
antigen VAR2CSA confers specific … that can induce a broad anti-adhesive antibody response is …

Evaluation of the Antigenic Diversity of Placenta-Binding Plasmodium falciparum Variants and the Antibody Repertoire among Pregnant Women

M Hommel, SR Elliott, V Soma, G Kelly… - Infection and …, 2010 - Am Soc Microbiol
… which var2csa was shown to be the dominant var gene transcribed. We examined antibody
recognition … to specific domains of VAR2CSA induced by immunization of animals. Vaccine-…

[引用][C] Production of antibodies with specificity for variant surface antigens expressed by P. falciparum involved in the pathogenesis of pregnancy-associated malaria

L Barfod - Immunology and CMPCMP …, 2001

[PDF][PDF] Research The kinetics of antibody binding to Plasmodium falciparum VAR2CSA PfEMP1 antigen and modelling of PfEMP1 antigen packing on the membrane …

LM Joergensen, A Salanti, T Dobrilovic… - 2010 - malariajournal.biomedcentral.com
… to variable Plasmodium falciparum-infected erythrocyteBaculovirus-expressed
constructs induce immunoglobulin G that recognizes VAR2CSA on Plasmodium falciparum-infected

Functionally relevant proteins in Plasmodium falciparum host cell invasion

ME Patarroyo, MP Alba, R Rojas-Luna… - …, 2017 - Future Medicine
… all Pf Rh2 protein constructs were obtained which were … as they stimulate the immune system
to recognize and induce Abs … of immunoglobulin G antibodies to Plasmodium falciparum …

[PDF][PDF] Evidence for Globally Shared

A Salanti, L Misher, DL Narum, JD Rowe, M Dahlbäck… - Infect. Immun, 2008 - Citeseer
… , recombinant VAR2CSA proteins are recognized in a gender… protein expression was induced
by adding methanol to a 0.5… antigens of Plasmodium falciparum-infected erythrocytes and …

Rationale for pregnancy-associated malaria vaccination predicated on antibody-mediated immunity

A Taylor-Robinson, L Morley, E Kane - 2013 - acquire.cqu.edu.au
… An erythrocytic vaccine, such as one inducing a response to … women can recognise a number
of strains of the VAR2CSA-… the ability to induce antibodies using this construct has been …

Limited Cross-Reactivity among Domains of the Plasmodium falciparum Clone 3D7 Erythrocyte Membrane Protein 1 Family

L Joergensen, L Turner, P Magistrado… - Infection and …, 2006 - Am Soc Microbiol
… by a gradual acquisition of specific immunoglobulin G (IgG) against … recognition of bacterial
and baculovirus-expressed … CIDR domains have previously been shown to induce cross-…

Pregnancy-associated malaria: parasite binding, natural immunity and vaccine development

B Gamain, JD Smith, NK Viebig, J Gysin… - International journal for …, 2007 - Elsevier
… To date, baculovirus expressed var2CSA recombinant proteins have been able to induce
that mediate the adherence of Plasmodium falciparum-infected erythrocytes to the placenta …