[HTML][HTML] Role of microglial amylin receptors in mediating beta amyloid (Aβ)-induced inflammation

W Fu, V Vukojevic, A Patel, R Soudy… - Journal of …, 2017 - Springer
… of Aβ or human amylin (hAmylin)-induced depression of hippocampal long-term potentiation,
a cellular surrogate of memory [20]. Herein, we show that amylin receptors are not only …

Amylin receptor ligands reduce the pathological cascade of Alzheimer's disease

…, JM Hooker, N Kowall, Q Tao, TD Stein, B Wolozin… - …, 2017 - Elsevier
Amylin treatment also improved more long-term spatial … in the cortex, the thalamus and the
hippocampus region as shown by … of amylin treatment in our AD models were mediated by the …

[HTML][HTML] An unbalanced synaptic transmission: cause or consequence of the amyloid oligomers neurotoxicity?

M Sciaccaluga, A Megaro, G Bellomo… - International Journal of …, 2021 - mdpi.com
… induce NGFR -mediated neuronal death through the p75 neurotrophin receptor, which is
a … NMDA-dependent long term potentiation (LTP) induction in the hippocampal CA1 and …

Amylin and amylin receptors in Alzheimer's disease

W Fu, JH Jhamandas - Genetics, Neurology, Behavior, and Diet in …, 2020 - Elsevier
Long-term potentiation (LTP) is a process involving persistent … felt to be mediated by neuronal
amylin receptors, a notion … , cAC253, to amylin receptors within the hippocampus. These in …

[HTML][HTML] Cyclic AC253, a novel amylin receptor antagonist, improves cognitive deficits in a mouse model of Alzheimer's disease

R Soudy, A Patel, W Fu, K Kaur, D MacTavish… - Alzheimer's & Dementia …, 2017 - Elsevier
… -induced impairment of hippocampal long-term potentiation. … Multiple receptors have been
implicated in mediating Aβ … -induced depression of hippocampal long-term potentiation (LTP), …

[HTML][HTML] Extracellular vesicles enriched with amylin receptor are cytoprotective against the Aß toxicity in vitro

R Soudy, R Kimura, W Fu, A Patel, J Jhamandas - Plos one, 2022 - journals.plos.org
… Aβ oligomer-mediated long term potentiation (LTP) impairment in mouse hippocampal slices
[… Effects of AMY3 EVs on Aβ-induced depression of hippocampal long term potentiation (LTP…

[HTML][HTML] Genetic depletion of amylin/calcitonin receptors improves memory and learning in transgenic Alzheimer's disease mouse models

A Patel, R Kimura, W Fu, R Soudy, D MacTavish… - Molecular …, 2021 - Springer
… to human amylin- and Aβ-induced depression of hippocampal long-term potentiation (LTP) …
of these target receptors for Aβ could attenuate the amyloid-induced neuroinflammation, …

Amylin receptor: a potential therapeutic target for Alzheimer's disease

W Fu, A Patel, R Kimura, R Soudy… - Trends in Molecular …, 2017 - cell.com
… , administration of amylin receptor-based peptides has … amylin receptor could be considered
a potential therapeutic target for AD, and present the rationale for using amylin receptor

Astrocytic glutamatergic transporters are involved in Aβ-induced synaptic dysfunction

S Huang, H Tong, M Lei, M Zhou, W Guo, G Li, X Tang… - Brain research, 2018 - Elsevier
… established that hippocampal long-term potentiation (LTP) is … , inhibited LTP and facilitated
long-term depression (LTD), thus … Soluble Aβ-impaired hippocampal LTP is mediated by …

[HTML][HTML] Notoginsenoside R1 increases neuronal excitability and ameliorates synaptic and memory dysfunction following amyloid elevation

S Yan, Z Li, H Li, O Arancio, W Zhang - Scientific reports, 2014 - nature.com
… on Aβ oligomers-induced reduction of hippocampal long-term potentiation (LTP), a form of
depression of hippocampal long-term potentiation is associated with the amylin receptor 52 . …