[HTML][HTML] Insulin and insulin resistance in Alzheimer's disease

A Sędzikowska, L Szablewski - International journal of molecular sciences, 2021 - mdpi.com
… in hippocampal synaptic plasticity by favoring long-term … -mediated downregulation of
hypothalamic insulin receptors … associated with long-term depression and long-term potentiation, …

Effects of insulin-like growth factor 1 on synaptic excitability in cultured rat hippocampal neurons

C Xing, Y Yin, R Chang, X Gong, X He, Z Xie - Experimental neurology, 2007 - Elsevier
… it also prevents β amyloid-induced death of hippocampal neurons. … the intracellular signaling
mechanisms mediating these effects. … IGF-1 elicits long-term depression in cultured Purkinje …

[HTML][HTML] Inhibiting tumor necrosis factor-α before amyloidosis prevents synaptic deficits in an Alzheimer's disease model

C Cavanagh, YC Tse, HB Nguyen, S Krantic… - Neurobiology of …, 2016 - Elsevier
Long-term potentiation … Next, we used a hippocampus-dependent inhibitory avoidance
task to … protein and preventing downstream signaling through the receptor. This mechanism of …

Soluble protein oligomers as emerging toxins in Alzheimer's and other amyloid diseases

ST Ferreira, MNN Vieira, FG De Felice - IUBMB life, 2007 - Wiley Online Library
… (IAPP, also known as amylin) are a characteristic pathological … to inhibit longterm potentiation
(LTP) in hippocampal slices (… ) beta-Amyloid-induced dynamin 1 degradation is mediated

Ultrasound delivery of a TrkA agonist confers neuroprotection to Alzheimer-associated pathologies

K Xhima, K Markham-Coultes, R Hahn Kofoed… - Brain, 2022 - academic.oup.com
… , avoid activation through the p75 neurotrophin receptor (p75 … ’s disease and their long-term
use may also have disease-… a treatment paradigm using MRIgFUS-mediated delivery of …

[HTML][HTML] Preventing synaptic deficits in Alzheimer's disease by inhibiting tumor necrosis factor alpha signaling

C Cavanagh, TP Wong - IBRO reports, 2018 - Elsevier
hippocampus of … hippocampal synaptic (long-term potentiation) and cognitive function (passive
avoidance) than control mice (Cavanagh et al., 2016). Moreover, enhanced hippocampal

Glutamate system, amyloid [Beta] peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathology

MD Jack Jhamandas - Journal of Psychiatry & Neuroscience …, 2013 - search.proquest.com
… formation through processes such as long-term potentiation and … receptor, p75 neurotrophin
receptor, amylin or α7 nicotinic … which tau mediates β amyloidinduced neurodegeneration. J …

Β-amyloid and oxidative stress: Perspectives in drug development

G Caruso, SF Spampinato, V Cardaci… - Current …, 2019 - ingentaconnect.com
… affecting both long term depression and long term potentiation [… Sub-Toxic human amylin
fragment concentrations promote … Integrins mediate beta-amyloid-induced cell-cycle activation …

[HTML][HTML] Modes of Aβ toxicity in Alzheimer's disease

J Götz, A Eckert, M Matamales, LM Ittner… - Cellular and Molecular Life …, 2011 - Springer
… We also discuss the role of miRNAs in mediating the toxic … Toxicity mediated by any
particular receptor may not … peptides Aβ and human amylin, respectively, indicates that the …

Alzheimer's disease and Aβ toxicity: from top to bottom

DH Small, SS Mok, JC Bornstein - Nature Reviews Neuroscience, 2001 - nature.com
… In addition to the biochemical pathways that mediate LTP … on the channel itself or through
another receptor (such as the … influence long-term potentiation (LTP) or long-term depression (…