… regulate brain energy metabolism, how such mechanisms are altered during aging and in
neurodegenerative disorders, and the potential applications to brain health and disease of …

… metabolic processes. The human brain is the prime controller of organismal metabolism, …
Brain metabolism requires the delivery of nutrients and energy fuel from outside [4,11,12,13,…

… review of the impact of metabolism, diet and microbiota in neurodegeneration, by affecting
simultaneously several aspects of health regarding energy metabolism, immune system and …

… -inflammatory axis (Yin et al., 2016) encompassing the bioenergetic activity, brain inflammatory
responses, and their redox regulation in healthy brain aging and neurodegenerative …

… in the aging process, with a specific focus on the brain. Starting from the ‘mitochondrial
theory of aging’, we will discuss why the brain seems to be so sensitive to the age-related …

… neurodegenerative diseases are associated with brain aging. Brain aging is associated
with anatomical and functional deterioration, which can result in neurodegenerative diseases. …

… aging and the early stages of neurodegenerative diseases. Critical Issues: This review focuses
on a coordinated metabolic … which impair this metabolic network during brain aging and …

… age-related decrements in neuronal function, health care costs will continue to rise exponentially.
Applying molecular biological approaches to slow aging in … to increase healthy aging, …

… —of metabolic traits and their alterations in the brain and in fluids … biomarkers of aging and
neurodegenerative diseases. Here, … of CNS aging and certain age-related neurodegenerative …

… to AD, PD, DLB, and CVD in the brains of nondemented elderly people represent early
stages of these diseases rather than healthy aging. We conclude that early pathological disease-…