… capacity in healthy aging is a … that healthy aging is associated with a reduction in brain
cortical neuronal mitochondrial energy production and altered glial mitochondrial metabolism. …

… CI) even in optimally healthy individuals. We critically evaluated the notion that oxidative
stress increases in aging brain. Rigorous studies show logarithmic age-dependent increases in …

… metabolism in brain (CMRO 2 ), cerebral blood flow (CBF), and oxygen extraction fraction
(OEF) in the brain are important indices of healthy aging… these variables in healthy volunteers, …

… Holding cerebrospinal fluid (CSF) lactates as an indirect measure of brain metabolic
activity, we first compared CSF lactate levels from patients with Alzheimer's disease (AD)—stratified …

… Accumulating evidence suggests that AD is closely related to a dysfunction of both insulin
signaling and glucose metabolism in the brain, leading to an insulin‐resistant brain state. Four …

… other forms of brain injury and chronic neurodegeneration. … brain metabolism is a process
of compartmentalization, these metabolites undergo complex intercellular transport in the brain…

… in age-related neurodegeneration in the developing brain … during brain development with
relevance to brain aging are of crucial … with relevance to aging; (2) neurodegenerative disease (…

… Here, we summarize current knowledge on how ketogenic interventions support brain
metabolism and discuss the therapeutic role of ketones in neurodegenerative disease, …

… of maintaining certain age-related features to accurately model and neurodegeneration.
Finally, we will discuss projections and potential uses of iNs to study brain aging and NDD to …

… activation, whereas risk factor management and pharmacological interventions can promote
a healthy aging. Aged microglia changes depend both on gained and lost functions. They …