… all the bacterial secretion systems, the Sec system, the focus of the present review, mediates
the export of most of the secretory and membrane proteins [… The membrane-embedded Sec …

… The central component of the Sec system is the transmembrane SecYEG channel (also
known as the SecYEG translocon; SEC61 in eukaryotes; Fig. 1c), which translocates …

… secreted across the inner membrane through the Sec system contain a … exported proteins
(Figure 1). The signal peptides of preproteins to be transported via the Sec pathway in bacteria, …

… , that the load on the Sec system is less than we have believed … enzymes necessary to
break down large molecules for … gate to allow translocation to the other side of the membrane. …

… It forms a helix-loop-helix structure that contacts on one side NBF2 and on the other side the
… Although most membrane proteins insert into the membrane via the Sec system, in recent …

… TMs 2b and 3 on one side and helices 7 and 8 on the other side of SecY (Hizlan et al. (…
negatively affects bacterial growth and their presence stimulates protein export (Pogliano & …

… recent developments in bacterial protein traffic that were … 2 and 7, on the opposite side of
the barrel from Sec61β could … go beyond the use of protein export systems in cell factories for …

… in addition to proteins exported via the Sec translocon, SecB … only, to proteins normally
targeted to the Sec system by SecB … the mature protein and are either helix breaking amino acids, …

… The Sec system is involved in the translocation of precursor … that resembles the bacterial
N-tail export in its energetics and … peptide inserts into micelles as a dynamic helix-break-helix …

… of proteins that are exported from the site of synthesis of all bacterial proteins, the cytoplasm,
into the … Breaking the contact at the side site on SecB within a wild-type complex results in …