C-reactive protein attenuates endothelial progenitor cell survival, differentiation, and function: further evidence of a mechanistic link between C-reactive protein and …

S Verma, MA Kuliszewski, SH Li, PE Szmitko, L Zucco… - Circulation, 2004 - Am Heart Assoc
… , and the mobilization and differentiation of endothelial progenitor cells (EPCs) has been
shown to be important in this process. An elevated level of C-reactive protein (CRP) has …

C-reactive protein alters antioxidant defenses and promotes apoptosis in endothelial progenitor cells

H Fujii, SH Li, PE Szmitko, PWM Fedak… - … , and vascular biology, 2006 - Am Heart Assoc
Objective— C-reactive protein (CRP) has been suggested to participate in the development
of atherosclerosis, in part, by promoting endothelial dysfunction and impairing endothelial

C-reactive protein impairs angiogenic functions and decreases the secretion of arteriogenic chemo-cytokines in human endothelial progenitor cells

W Suh, KL Kim, JH Choi, YS Lee, JY Lee… - Biochemical and …, 2004 - Elsevier
… This proatherogenic CRP was speculated to have a role in attenuating angiogenic functions
of human endothelial progenitor cells (EPCs), possibly impairing vascular regeneration and …

C-reactive protein down-regulates endothelial nitric oxide synthase expression and promotes apoptosis in endothelial progenitor cells through receptor for advanced …

J Chen, J Jin, M Song, H Dong, G Zhao, L Huang - Gene, 2012 - Elsevier
… effects were attenuated during RAGE protein expression … C-reactive protein (CRP) is a
prototypic marker of inflammation … (RAGE) expression in endothelial progenitor cells (EPCs) [3]. …

C-reactive protein exerts angiogenic effects on vascular endothelial cells and modulates associated signalling pathways and gene expression

MM Turu, M Slevin, S Matou, D West, C Rodríguez… - BMC cell biology, 2008 - Springer
C-reactive protein (CRP) is an acute phase reactant whose expression in the vascular wall,
in particular, in reactive plaque regions, and circulating levels increase in patients at high …

Circulating endothelial progenitor cells, C-reactive protein and severity of coronary stenosis in Chinese patients with coronary artery disease

HY Wang, PJ Gao, KD Ji, WF Shen, CL Fan, L Lu… - Hypertension …, 2007 - nature.com
… numbers and activity of circulating endothelial progenitor cells (EPCs) correlate with severity
… Li SH, et al: C-reactive protein attenuates endothelial progenitor cell survival, differentiation, …

Direct proinflammatory effect of C-reactive protein on human endothelial cells

V Pasceri, JT Willerson, ETH Yeh - Circulation, 2000 - Am Heart Assoc
… Background—The acute-phase reactant C-reactive protein (CRP) is an important risk factor
for coronary heart disease. However, the possible effects of CRP on vascular cells are not …

Opposing effects of monomeric and pentameric C-reactive protein on endothelial progenitor cells

I Ahrens, H Domeij, SU Eisenhardt, D Topcic… - Basic Research in …, 2011 - Springer
C-reactive protein are predictive of adverse cardiovascular events [23, 51, 71], decreased
numbers of circulating endothelial progenitor cells … the hypothesis that C-reactive protein might …

Association between circulating endothelial progenitor cells and hs-CRP in patients with diabetes

M Koshikawa, A Izawa, T Tomita… - The British Journal …, 2010 - journals.sagepub.com
… tivity C-reactive protein (hs-CRP) in patients with diabetes. … C-reactive protein and other
markers of inflammation in the … A self-fulfilling prophecy: C-reactive protein attenuates nitric …

C-reactive protein downregulates endothelial NO synthase and attenuates reendothelialization in vivo in mice

R Schwartz, S Osborne-Lawrence, L Hahner… - Circulation …, 2007 - Am Heart Assoc
… Further studies are now indicated to determine whether CRP impairs the function of
endothelial progenitor cells in vivo, which are released from the bone marrow in an NO-dependent …