… C3 bot transferase, an exoenzyme produced by Clostridium … show that the C3 bot mutant,
C3 E174Q , which lacks RhoA … counteracted the axonotrophic effects we observed in vitro in a …

… C3 is taken up by eukaryotic cells although lacking an uptake … ADP-ribosyltransferase activity
was measured by an in vitro … the effect of vimentin knock down on the C3 uptake. As shown …

… used with great effect in vivo to enhance regeneration of damaged … In vivo studies targeting
RhoA with C3 exoenzyme have … 2004 Axonal regeneration and lack of astrocytic gliosis in …

… Live in vivo imaging further showed that on taxol treatment in … effect: the classical paradigm
of axon regeneration elicited by … in neurodegenerative diseases that lack a defined time 0? …

… on the molecular mechanisms and functional consequences of ADP-… Intracellularly expressed
C3bot did not induce axon growth. … of how the C3-like exoenzymes, which lack a specific …

… effect of Rho-GTPases in the peripheral nerve regeneration remains uncertain. It is clear that
Rho plays a role in peripheral … botulinum exoenzyme C3 and affects actin microfilaments in …

… their inhibitory effects on axon regeneration. However, CNS … the DRG lack dendrites
and are pseudo-unipolar with a peripheral … In vivo imaging studies have shown that pre-conditioning …

… (594) developed a new recombinant form of C3 that has … astrogliosis stops axonal regeneration
in vivo is often inferred… obstacles are responsible for lack of regeneration in the spinal …

… of peripheral nerve regeneration consist in the lack of axonal … ), which are inhibited by
bacterial exoenzymes such as C3. … its reduction promotes axonal growth in vitro (Wnt proteins are …

… While the exoenzyme C3 transferase is a potent RhoA … 24 kDa C3 protein to enter cell is very
low because it lacks the … a sustainable in vivo release system for TAT-C3, we encapsulated …