… This review overviews the expression of CCR4 in various T … CCR4; its expression on normal
and malignant T cells and its significance as a therapeutic target in cancer immunotherapy…

… immune privilege, making CCR4 on Treg cells a novel target for cancer immunotherapy. HL
… We believe that anti-CCR4 mAb could be an ideal treatment modality for patients with CCR4…

… Figure 1CCR4 as a target both for tumor cell lysis and to boost immune response to cancer
via regulatory T cell blockade. (A) Innate immune cells such as dendritic cells (DCs) and …

… anti-CCR4 mAb could be a novel treatment modality for patients with CCR4-positive HL. …
HL cell lines but also tumor cells from certain HL patients express CCR4. To our knowledge, no …

… The immunopathology of MF and SS is complex, but recent advances in tumor microenvironment
understanding have identified CCR4 as a promising therapeutic target. CCR4 is widely …

… Cancer immunotherapy with monoclonal antibodies that effectively block PD(L)-1 and
CTLA-4 are designed to enhance antitumor immunity and have shown promise in the …

… renal cancer, Affi 5, a CCR4 blocking mAb, reduced tumor growth … CCR4 is now considered
a target for renal carcinoma … the use of mAbs against CCR4 especially in patients previously …

… Recognition of the importance of CCR4 on tumor and Treg cells in different types of cancer
and … CCR4 as a novel molecular target of cancer immunotherapy, and developed therapeutic …

… before CCR4-targeted therapies … of CCR4 on Th2 cells makes it a potential therapeutic
target for allergic diseases. Due to the expression of CCR4 on Treg cells, the blockade of CCR4 …

… Drug development The dominant expression of CCR4 in T h 2 cells makes it a potential
therapeutic target for … Furthermore, because of the expression of CCR4 on T reg cells, CCR4 …