Current controversies in determining the main mechanisms of atrial fibrillation

U Schotten, D Dobrev, PG Platonov… - Journal of internal …, 2016 - Wiley Online Library
… AF, the contribution of ectopic (triggered) activity caused by … in the right and left atria in patients
with paroxysmal AF, … the atrial myocardium showed strong and significant correlation with …

Role of inflammatory signaling in atrial fibrillation

L Scott Jr, N Li, D Dobrev - International journal of cardiology, 2019 - Elsevier
… Increase in the level of TNF-α correlates with the different stages of AF patients relative to …
The cellular and molecular mechanisms underlying atrial ectopic activity and the reentrant …

Electrophysiological remodeling in human atrial fibrillation

DRV Wagoner - Pacing and clinical electrophysiology, 2003 - Wiley Online Library
atrial fibrillation myocytes isolated from patients in normal sinus rhythm or persistent AF are
shown in the top panel. The molecular correlates … mediator of ectopic atrial electrical activity. …

Mechanisms of atrial fibrillation

RS Wijesurendra, B Casadei - Heart, 2019 - heart.bmj.com
… make ectopic activity more likely by producing changes in Ca 2+ handling that promote both
triggered activity … dilatation may support re-entry directly, but is also strongly correlated to the …

Atrial remodeling and atrial fibrillation: recent advances and translational perspectives

S Nattel, M Harada - Journal of the American College of Cardiology, 2014 - jacc.org
… of triggered ectopic activity and for the activation of Ca 2+ -related cell signaling that …
and their plasma concentrations have been found to correlate with the risk of AF, suggesting …

Atrial remodeling and atrial fibrillation: mechanisms and implications

S Nattel, B Burstein, D Dobrev - Circulation: Arrhythmia and …, 2008 - Am Heart Assoc
… Even if AF is initially maintained by ectopic activity or single-circuit reentry in a given
patient, ATR-induced spatially heterogeneous refractoriness abbreviation creates conditions …

[HTML][HTML] Atrial fibrillation and fibrosis: beyond the cardiomyocyte centric view

M Miragoli, AV Glukhov - BioMed research international, 2015 - hindawi.com
… SAN activity and conduction, but enhanced atrial ectopic activityactivity and conduction but
enhanced atrial ectopic activity … frequency correlate with myofibroblast density. Spontaneous …

Aging modulates the substrate and triggers remodeling in atrial fibrillation

YK Lin, YA Chen, TI Lee, YC Chen, SA Chen… - Circulation …, 2018 - jstage.jst.go.jp
activity in the sinoatrial node (SAN) compared with PVs of rabbits, which may facilitate ectopic
electrical activity … to the atrial tissuen, 73 , 74 which provides a molecular correlation to the …

[HTML][HTML] Altered calcium handling produces reentry-promoting action potential alternans in atrial fibrillation–remodeled hearts

T Liu, F Xiong, XY Qi, J Xiao, L Villeneuve, I Abu-Taha… - JCI insight, 2020 - ncbi.nlm.nih.gov
… Ca 2+ releases, causing spontaneous atrial ectopic activity, but also promote alternans …
SERCA2a downregulation is a principal correlate of repolarization alternans in heart failure (…

Pathophysiological mechanisms of atrial fibrillation: a translational appraisal

U Schotten, S Verheule, P Kirchhof… - Physiological …, 2011 - journals.physiology.org
… Under these conditions, ectopic activity originating from the pulmonary veins or other sites
is … Differences in APD between regions correlated to systematic differences in ion channel …