Mutation E169K in junctophilin-2 causes atrial fibrillation due to impaired RyR2 stabilization

DL Beavers, W Wang, S Ather, N Voigt… - Journal of the American …, 2013 - jacc.org
correlation between atrialectopic activity often arises from the pulmonary vein region, there
is also evidence for highly frequent focal sources in the right atrium in up to 33% of patients (…

Dynamic remodeling of intracellular Ca2+ signaling during atrial fibrillation

M Greiser, U Schotten - Journal of molecular and cellular cardiology, 2013 - Elsevier
… aims to elucidate the molecular and sub-cellular mechanisms … phase of AF, if ectopic focal
discharges contributed significantly to … linearly correlated to the incidence of ectopy during AF. …

[HTML][HTML] Cardiomyocyte inflammasome signaling in cardiomyopathies and atrial fibrillation: mechanisms and potential therapeutic implications

G Chen, MG Chelu, D Dobrev, N Li - Frontiers in physiology, 2018 - frontiersin.org
… ryanodine receptor type-2 (RyR2), which might represent the molecular correlates of ectopic
activity as reflected by the higher incidence of premature atrial contractions. In addition, the …

[HTML][HTML] The correlation between gut microbiome and atrial fibrillation: pathophysiology and therapeutic perspectives

N Li, L Wang, L Li, MZ Yang, QX Wang, XW Bai… - Military Medical …, 2023 - Springer
… The incidence and prevalence of atrial fibrillation (AF) are continuously escalating as the …
In this review, we summarized the evidence for a bidirectional correlation between AF and the …

Coronary heart disease and atrial fibrillation: a vicious cycle

F Liang, Y Wang - American Journal of Physiology-Heart …, 2021 - journals.physiology.org
… (CHD) complicated by atrial fibrillation (AF) is rising rapidly. A strong correlation between the
two … In summary, research on focal ectopic activity after ACS is still inconclusive, and it may …

The value of basic research insights into atrial fibrillation mechanisms as a guide to therapeutic innovation: a critical analysis

J Heijman, V Algalarrondo, N Voigt… - Cardiovascular …, 2016 - academic.oup.com
… More work is clearly needed to clarify the role of abnormal Ca 2+ handling in the generation
of atrial ectopic activity and the initiation/maintenance of AF in specific patient populations. …

Genes and atrial fibrillation: a new look at an old problem

D Fatkin, R Otway, JI Vandenberg - Circulation, 2007 - Am Heart Assoc
Molecular correlates for most of the ionic currents that contribute to the atrial action potential
have been … Atrial ectopic activity may be sufficient to maintain AF or may trigger reentry. …

Ryanodine receptor–mediated calcium leak drives progressive development of an atrial fibrillation substrate in a transgenic mouse model

N Li, DY Chiang, S Wang, Q Wang, L Sun, N Voigt… - Circulation, 2014 - Am Heart Assoc
… of atrial ectopic activity revealed a higher incidence of atrial … that correlate with the severity
and persistence of AF in patients. … to gain new insights into the molecular pathogenesis of AF. …

Enhanced cardiomyocyte NLRP3 inflammasome signaling promotes atrial fibrillation

C Yao, T Veleva, L Scott Jr, S Cao, L Li, G Chen… - Circulation, 2018 - Am Heart Assoc
… The proarrhythmic consequences of increased RyR2 protein levels as a molecular correlate
of triggered (ectopic) activity are supported by a number of previous studies in human atrial

… Sarcoplasmic Reticulum Ca2+ Leak and Increased Na+-Ca2+ Exchanger Function Underlie Delayed Afterdepolarizations in Patients With Chronic Atrial Fibrillation

N Voigt, N Li, Q Wang, W Wang, AW Trafford… - Circulation, 2012 - Am Heart Assoc
… in cAF provides a molecular correlate for increased SR Ca 2… mechanisms leading to cellular
ectopic activity in cAF. cAF … gain as a mechanism of increased ectopic activity in cAF. CaMKII …