Repolarization alternans reveals vulnerability to human atrial fibrillation

SM Narayan, MR Franz, P Clopton, EJ Pruvot… - Circulation, 2011 - Am Heart Assoc
patients were included in our report that an atrial APD restitution slope >1 explains AF initiation
from ectopic beats… This model adjusts for correlated observations within individuals. A log …

Altered expression of hyperpolarization-activated cyclic nucleotide-gated channels and microRNA-1 and-133 in patients with age-associated atrial fibrillation

YD Li, YF Hong, Y Yusufuaji… - Molecular …, 2015 - spandidos-publications.com
ectopic premature beats that trigger atrial fibrillationpatients with persistent atrial fibrillation,
while levels of miR-1 were lower. The prevalence of atrial fibrillation was positively correlated

Inflammatory signalling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology

D Dobrev, J Heijman, R Hiram, N Li… - Nature Reviews …, 2023 - nature.com
… Increased atrial ectopy 44,45,46 in experimental pericarditis is associated with DADs and
cellular triggered activity 47 . Atrial structural remodelling in these animal models is …

[HTML][HTML] Cellular and molecular mechanisms of arrhythmia by oxidative stress

AA Sovari - Cardiology Research and Practice, 2016 - hindawi.com
… Both atrial fibrillation and heart failure, a condition with increased arrhythmic risk, are … , which
is potentially arrhythmogenic via increased ectopic activity [52]. Another important factor that …

Novel molecular targets for atrial fibrillation therapy

D Dobrev, L Carlsson, S Nattel - Nature reviews Drug discovery, 2012 - nature.com
… the underlying molecular determinants of atrial fibrillation, and … anti-atrial fibrillation drugs,
on the molecular and structural … ectopic activity to induce re-entry in remodelled vulnerable …

Postoperative atrial fibrillation: mechanisms, manifestations and management

D Dobrev, M Aguilar, J Heijman, JB Guichard… - Nature Reviews …, 2019 - nature.com
… An increase in sinus rate and atrial ectopic activity, pointing to an increased sympathetic …
cardiac-nerve activity also correlates with the burden of premature atrial contractions and the …

Heart failure and atrial fibrillation: from basic science to clinical practice

JP Ferreira, M Santos - International journal of molecular sciences, 2015 - mdpi.com
… for atrial re-entry and ectopic activity [7], promoting further arrhythmogenesis [37]. … This
study identified strong correlations between increasing abnormalities of LA structure and function …

A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice

W Dai, B Laforest, L Tyan, KM Shen, RD Nadadur… - Elife, 2019 - elifesciences.org
… We report a calcium transport mechanism for Tbx5-dependent ectopic activity. We show
that TBX5 is a critical regulator of SERCA-mediated SR calcium handling and that Tbx5-deficient …

Left versus right atrial difference in dominant frequency, K+ channel transcripts, and fibrosis in patients developing atrial fibrillation after cardiac surgery

MF Swartz, GW Fink, CJ Lutz, SM Taffet, O Berenfeld… - Heart rhythm, 2009 - Elsevier
… in left-versus-right frequency differences that correlate with inward rectifier potassium
channel expression. However, the molecular determinants of AF frequency in the human heart …

The C-terminal HCN4 variant P883R alters channel properties and acts as genetic modifier of atrial fibrillation and structural heart disease

I Weigl, P Geschwill, M Reiss, C Bruehl… - Biochemical and …, 2019 - Elsevier
… origin of ectopic activity promoting the initiation of AF [5]. Spontaneously active atrial myocytes
that highly express HCN4 [6] were identified as a cellular correlate of ectopic PV trigger, …