… in biofluids, especially in cerebrospinal fluid (CSF). Most … in total α-synuclein and an increase
in phosphorylated and oligomeric α-… In vitro studies have suggested that α-synuclein may …

… bodies and neurites in PD, and dementia with Lewy bodies; huntingtin inclusions in Huntington’s
disease… mutations were artificially enhancing the fibrillation of tau protein in vivo. Added …

… the parenchyma to the cerebrospinal fluid and across the blood-… neuronal dysfunction and
increases vulnerability to stress. … amyloid in vivo after 18 months of antibody treatment [125]. …

… in patients with PD and dementia with Lewy bodies than in … oligomer in the pathology of in
vitro neuronal cell death, and … periods of the patients groups could increase the reliability of …

… vivo experiments with animal models suggest that the misfolding, aggregation, and brain
deposition of α-synuclein (αSyn) in the form of Lewy bodies and Lewy … sonicated to increase the …

… is present in body fluids, such as plasma, cerebrospinal fluid (… in experimental systems
both in vivo and in vitro, where α-… help to clear α-synuclein and increase neuronal survival (2). …

… in Parkinson's disease and Lewy body dementia. Detrimental … -length α-syn in human
cerebrospinal fluid101 and, later, it … application of alpha-synuclein oligomers (α-synOs) and …

… of alpha-synuclein in the form of Lewy bodies and Lewy neurites. … in vivo and accelerate
cognitive dysfunction (10). Most notably, … increase in CSF levels of alpha-synuclein in PD-RBD …

… product from patients with PD or dementia with Lewy bodies with high … We initially seeded
the in vitro assembly of recombinant … levels in cerebrospinal fluid in Parkinson's disease are …

… Alterations in cerebrospinal fluid (CSF) and plasma Aβ42 levels slightly precede changes in
… on a molecular level and have described enhanced propagation and seeding of mixed tau-…