Characterization of the transition-metal-binding properties of hepcidin
C Tselepis, SJ Ford, AT McKie, W Vogel… - Biochemical …, 2010 - portlandpress.com
… , an interaction between copper and hepcidin had not been … characterize metal ion binding
to hepcidin and, using mutation analysis, determine the critical amino acids within hepcidin …
to hepcidin and, using mutation analysis, determine the critical amino acids within hepcidin …
The N-terminus of hepcidin is a strong and potentially biologically relevant Cu (II) chelator
… hepcidin. Our study focused on the model DTHFPI-NH 2 hexapeptide reflecting the N-terminal
motif of mature hepcidin… Based on these results we propose that hepcidin could exist as Cu…
motif of mature hepcidin… Based on these results we propose that hepcidin could exist as Cu…
An Overlooked Hepcidin–Cadmium Connection
D Płonka, MD Wiśniewska, MD Peris-Díaz… - International Journal of …, 2022 - mdpi.com
… (5R-hepcidin). … hepcidin we demonstrated that hepcidin can compete for Cd(II) ions with
metallothionein-2, a cellular cadmium target. This study enabled us to conclude that hepcidin …
metallothionein-2, a cellular cadmium target. This study enabled us to conclude that hepcidin …
Investigations of the Copper Peptide Hepcidin-25 by LC-MS/MS and NMR +
IM Abbas, M Vranic, H Hoffmann, AH El-Khatib… - International journal of …, 2018 - mdpi.com
… To our knowledge, none of the materials used for hepcidin analysis have been characterized
in this respect, yet. Even simple (non-chiral) amino acid analysis can be very useful for the …
in this respect, yet. Even simple (non-chiral) amino acid analysis can be very useful for the …
Iron, hepcidin, and the metal connection
O Loréal, T Cavey, E Bardou-Jacquet… - Frontiers in …, 2014 - frontiersin.org
Identification of new players in iron metabolism, such as hepcidin, which regulates
ferroportin and divalent metal transporter 1 expression, has improved our knowledge of iron …
ferroportin and divalent metal transporter 1 expression, has improved our knowledge of iron …
[HTML][HTML] The Cu (II) affinity constant and reactivity of Hepcidin-25, the main iron regulator in human blood
D Płonka, MD Wiśniewska, J Ziemska-Legięcka… - Journal of inorganic …, 2023 - Elsevier
… Hepcidin is an iron regulatory hormone that does not bind iron directly. Instead, its mature
25… The Cu(II)-hepcidin complex was previously studied, but due to poor solubility and difficult …
25… The Cu(II)-hepcidin complex was previously studied, but due to poor solubility and difficult …
Hepcidin in human iron disorders: diagnostic implications
JJC Kroot, H Tjalsma, RE Fleming… - Clinical …, 2011 - academic.oup.com
… of hepcidin and the current state-of-the-art in hepcidin assays. We furthermore summarize
human studies of hepcidin in … characterized by increased erythropoietic activity. A decrease in …
human studies of hepcidin in … characterized by increased erythropoietic activity. A decrease in …
[PDF][PDF] Hepcidin: Structure, Functions And Role In Hematological Disorders
M Saboor - Majmaah Journal of Health Sciences, 1970 - researchgate.net
… of hepcidin ie, hepcidin 20, 22 and 25. Hepcidin 20 and 22 are the truncated hepcidin having
… ACD is characterized by normocytic normochromic red cells, decreased serum iron levels …
… ACD is characterized by normocytic normochromic red cells, decreased serum iron levels …
Cellular dynamics of transition metal exchange on proteins: a challenge but a bonanza for coordination chemistry
JM Moulis - Biomolecules, 2020 - mdpi.com
… and mechanistic properties of ill-characterized metalloproteins at … hepcidin without evidence
of transition metal binding [64]. Similarly, production of C-terminal histidine-tagged hepcidin …
of transition metal binding [64]. Similarly, production of C-terminal histidine-tagged hepcidin …
Transition metals at the host–pathogen interface: how Neisseria exploit human metalloproteins for acquiring iron and zinc
… systems are the most well characterized to date and are … hepcidin to inhibit iron transport
into the bloodstream [36]. … The hCP heterodimer has two transition metal-binding sites …
into the bloodstream [36]. … The hCP heterodimer has two transition metal-binding sites …