… of the pro-inflammatory mediator cyclooxygenase-2 (COX-2) are pharmacological agents
with important anti-cancer activities [1]. After the identification of the second inducible form of …

… Because sulfasalazine inhibits the absorption of folate 39 and folate deficiency may be …
risk of sporadic colon cancer, 40 it is also possible that the lack of a chemopreventive effect with …

… Inhibition by NSAIDs of the growth of colon tumors induced by chemical carcinogens in rodents
and the regression, induced by sulindac, of large-bowel … patients with colon cancer who …

… , prostate and colon cancer. The paradigm for developing new chemopreventive agents has
… This review will summarise the current status of the field of chemoprevention and highlight …

… of prostaglandins and the cyclooxygenase (COX) enzymes in colorectal tumorigenesis.
COX-2 inhibition is an attractive target in colorectal cancer chemoprevention. The regression of …

Cancer is a cluster of diseases which involves variation in the status and activation of
multiple genes that impart an advantage to survive and unexhausting proliferative potential to …

… It was shown that the COX-2 inhibitor NS-398 induced apoptosis in colon cancer cells by
the release of cytochrome c and activation of caspase-9 and caspase-3 ( 21 ). Diminishing the …

… The evidence has been strongest for an effect on colorectal cancers (CRCs) (1, 2), especially
in high-risk groups such as those with Lynch syndrome (3). Support has also come from …

… important, particularly in colorectal cancer in promoting the acquisition of a progenitor or
stem cell-like phenotype contributing to the limitless replicative potential in cancer (Citation58). …

… of cyclooxygenase-2 (Cox-2) inhibitors in invasive bladder … growth of HCA-7, a human colon
cancer cell line, in nude mice … candidate for an anti-tumour or chemopreventive reagent for …