… factors have a major role in shaping the function of adaptive immune cells such as T and B
cells… Accumulated cholesterol in innate immune cells enhances NLRP3 inflammasome activity…

… results from a passive buildup of cholesterol in the artery wall. Yet, … More recent studies in
gene-targeted mice show that … for CVD, LDL participates causally in the disease process. The …

… This underlines the need to develop immune-targeted … a core region of activated immune
cells, cholesterol crystals and … aortic CD11c–YFP + antigen-presenting cells (APCs) and T cells …

… that cholesterol accumulation in leukocytes is causally associated with the development
of autoimmune diseases. … that cholesterol overload in CD11c + antigen-presenting cells (APCs) …

… ) mediate the efflux of cholesterol from immune cells via liver X … cholesterol accumulation
and autoimmunity. Mice lacking … The metabolism of immune cells is already targeted by a drug …

… by increased immune cell infiltration, lipid accumulation, and … inflammation could be a
causal determinant of lesion severity … Abca1/Abcg1 in CD11c expressing cells 30 and reduces …

… by tumor cell–secreted factors, dependent on … the immune system. In the severe hyperlipidemia
model featuring genetic loss of both Apoe and Lxrb, cholesterol accumulation in CD11c + …

… Whether targeting cholesterol mobilization in immune cells … that CRP is not a causal factor
for atherosclerosis but, rather, … rather appropriate pathways should be targeted from a clinical …

… , immune dysfunction can be targeted by modifying cell … this cholesterol accumulation in
CD11c + cells, enhancing their capacity to present antigen and promoting autoimmune disease […

… , thereby increasing the risk of autoimmune diseases [21,22,… effect of CHB on cholesterol
metabolism in immune cells, we … in cholesterol levels and lipid raft formation on CD11c + DCs …