Amorphous solid dispersions: Utilization and challenges in preclinical drug development within AstraZeneca

AB Anane-Adjei, E Jacobs, SC Nash, S Askin… - International Journal of …, 2022 - Elsevier
choice of a suitable manufacturing technique for ASD development. In many cases, APIs for
which ASD’s are required, have extremely low solubility in solvents … initial ASD preparation

Polymeric amorphous solid dispersions: a review of amorphization, crystallization, stabilization, solid-state characterization, and aqueous solubilization of …

S Baghel, H Cathcart, NJ O'Reilly - Journal of pharmaceutical sciences, 2016 - Elsevier
… of amorphous solid dispersions (ASDs) products. … for the rational selection of polymers and
preparation techniques and … Piroxicam Solvent evaporation This study demonstrated that the …

Influence of solvent composition on the miscibility and physical stability of naproxen/PVP K 25 solid dispersions prepared by cosolvent spray-drying

A Paudel, G Van den Mooter - Pharmaceutical research, 2012 - Springer
… for the selection of the most suitable carrier. Moreover, the method of … an ASD prepared by
spray-drying can be rationally correlated with the properties of dispersing solvents or solvent

Effects of the preparation process on the properties of amorphous solid dispersions

S Huang, RO Williams - Aaps Pharmscitech, 2018 - Springer
… or isolation) the solvent in the solution to form an ASD. Typically, … Besides the formulation
factors, ASD preparation methods can … Therefore, the selection of drug and polymeric carriers is …

[HTML][HTML] Continuous formulation approaches of amorphous solid dispersions: significance of powder flow properties and feeding performance

E Szabó, B Démuth, DL Galata, P Vass, E Hirsch… - Pharmaceutics, 2019 - mdpi.com
… Since a lot of polymer-based ASD prepared by solvents method can be described as a
sticky powder, a fine concave screw would be the best choice for precise feeding. Based on …

Phase behavior of drug-hydroxypropyl methylcellulose amorphous solid dispersions produced from various solvent systems: Mechanistic understanding of the role of …

NA Mugheirbi, LI Mosquera-Giraldo… - Molecular …, 2018 - ACS Publications
solvent properties on the phase behavior of ASDs containing itraconazole (ITZ) and
hydroxypropylmethyl cellulose (HPMC) prepared … for selecting the proper solvent/solvent mixture …

Efficient development of sorafenib tablets with improved oral bioavailability enabled by coprecipitated amorphous solid dispersion

S Song, C Wang, S Wang, RA Siegel… - International journal of …, 2021 - Elsevier
… in solvents that are compatible with the polymers used in preparing ASDs. HME is a …
To select a suitable grade of HPMC-AS for preparing ASD of SOR, in vitro release of SOR …

Use of Time-Domain NMR for 1H T1 Relaxation Measurement and Fitting Analysis in Homogeneity Evaluation of Amorphous Solid Dispersion

K Okada, T Ono, Y Hayashi, S Kumada… - Journal of Pharmaceutical …, 2024 - Elsevier
… One was inhomogeneous ASD (ASD melt ) prepared by a … was homogeneous ASD (ASD
solvent ) prepared by a solvent … , selecting a function using only residuals is not appropriate, …

[HTML][HTML] Advancing Drug Delivery Paradigms: Polyvinyl Pyrolidone (PVP)-Based Amorphous Solid Dispersion for Enhanced Physicochemical Properties and …

A Rusdin, A Mohd Gazzali, N Ain Thomas… - Polymers, 2024 - mdpi.com
… include selecting suitable solvent(s), dissolving the drug and polymer(s), evaporating the
solvent… During the preparation of ASD, it is crucial to maintain suitable processing conditions to …

[HTML][HTML] Innovations in thermal processing: hot-melt extrusion and KinetiSol® dispersing

DK Tan, DA Davis Jr, DA Miller, RO Williams III… - Aaps Pharmscitech, 2020 - Springer
… Therefore, the selection of suitable polymers is essential to inhibit the … ASDs cost-effectively
at a large volume is a significant advantage over other solvent-based ASD preparation