Recent strategies in spray drying for the enhanced bioavailability of poorly water-soluble drugs
… used in the preparation of ASD … Selection of a suitable solvent system is one of the key
requirements when formulating an amorphous dispersion by spray drying. Usually the solvent …
requirements when formulating an amorphous dispersion by spray drying. Usually the solvent …
Melt Fusion Techniques for Solubility Enhancement: A Comparison of Hot Melt Extrusion and KinetiSol® Technologies
… selection of suitable polymer and % drug load to prepare … by a solvent-controlled
coprecipitation technique to prepare … also suitable to prepare ASDs that cannot be prepared using …
coprecipitation technique to prepare … also suitable to prepare ASDs that cannot be prepared using …
Balancing solid-state stability and dissolution performance of lumefantrine amorphous solid dispersions: the role of polymer choice and drug–polymer interactions
… of polymer selection in the formulation of ASDs, where a … prepared with the neutral
polymer, PVPVA. Lumefantrine is a … ASDs of different DLs were prepared using the solvent …
polymer, PVPVA. Lumefantrine is a … ASDs of different DLs were prepared using the solvent …
Effects of surfactants on itraconazole-HPMCAS solid dispersion prepared by hot-melt extrusion I: Miscibility and drug release
… been limited to ASDs prepared by spray drying using organic solvents, and the solvent-free …
, for the successful formulation of ASD, it is necessary to select a surfactant that is miscible …
, for the successful formulation of ASD, it is necessary to select a surfactant that is miscible …
Amorphous solid dispersions: Stability mechanism, design strategy and key production technique of hot melt extrusion
J Han, M Tang, Y Yang, W Sun, Z Yue, Y Zhang… - International Journal of …, 2023 - Elsevier
… satisfactory ASDs in terms of drug properties, carrier selection, … Fast preparation Difficult to
choose an appropriate solvent for co-… drugs and carriers are soluble in the low boiling solvents …
choose an appropriate solvent for co-… drugs and carriers are soluble in the low boiling solvents …
Utilizing Drug Amorphous Solid Dispersions for the Preparation of Dronedarone per os Formulations
A Kapourani, AE Manioudaki, KN Kontogiannopoulos… - Polymers, 2023 - mdpi.com
… The results in this study showed that the prepared ASDs … , Jung et al. prepared DRN-based
ASDs using a conventional solvent … of DRN ASDs, focusing, for the first time, on the selection (…
ASDs using a conventional solvent … of DRN ASDs, focusing, for the first time, on the selection (…
Development of nimesulide amorphous solid dispersions via supercritical anti-solvent process for dissolution enhancement
G Liu, L Gong, J Zhang, Z Wu, H Deng… - European Journal of …, 2020 - Elsevier
… A selection of the most relevant experiments and corresponding … In this study, NIM-ASDs
were successfully prepared by … A suitable combination of operating conditions for the …
were successfully prepared by … A suitable combination of operating conditions for the …
Myth or truth: The glass forming ability class iii drugs will always form single-phase homogenous amorphous solid dispersion formulations
… DCM was considered the first choice of solvent in this study … the amorphous state prepared
using solvent based methods. … However, for the ASDs prepared by film casting with PVPVA 64 …
using solvent based methods. … However, for the ASDs prepared by film casting with PVPVA 64 …
Continuous manufacturing and molecular modeling of pharmaceutical amorphous solid dispersions
… of dolutegravir prepared by quench cooling and solvent … was improved by ASDs prepared
by solvent evaporation, which … choice of an optimal technique for preparing ASDs(19, 93). …
by solvent evaporation, which … choice of an optimal technique for preparing ASDs(19, 93). …
Preparation and Evaluation of Siderol Amorphous Solid Dispersions: Selection of Suitable Matrix/Carrier
M Koromili, A Kapourani, A Koletti, G Papandreou… - AAPS …, 2022 - Springer
… an appropriate matrix/carrier for the preparation of SDR ASDs… dichloromethane (three times
for each solvent) for at least 48 h … out using mixtures of solvents appropriate for each group of …
for each solvent) for at least 48 h … out using mixtures of solvents appropriate for each group of …