Drug release and nanodroplet formation from amorphous solid dispersions: insight into the roles of drug physicochemical properties and polymer selection
… For HPMCAS ASDs, a total amount of 1 g of drug and polymer was dissolved in 20 mL of
1:1 methanol/DCM solvent. ASDs were then prepared by solvent evaporation using a Buchi …
1:1 methanol/DCM solvent. ASDs were then prepared by solvent evaporation using a Buchi …
Crystallization tendency of APIs possessing different thermal and glass related properties in amorphous solid dispersions
A Kapourani, E Vardaka, K Katopodis… - International Journal of …, 2020 - Elsevier
… crystallization tendency of the prepared ASDs showed no apparent … After solvent removal
the formation of ASD nano-films was … physically stable ASDs, the selection of a suitable matrix-…
the formation of ASD nano-films was … physically stable ASDs, the selection of a suitable matrix-…
[PDF][PDF] Solid dispersion as a technical solution to boost the dissolution rate and bioavailability of poorly water-soluble drugs
… prepare SDs by such as kneading, co-milling, fusion, solvent … The selection of appropriate
preparation method and carrier is … is used to prepare ASD in a large scale for heat-labile drugs.…
preparation method and carrier is … is used to prepare ASD in a large scale for heat-labile drugs.…
[HTML][HTML] Predicting process design spaces for spray drying amorphous solid dispersions
S Dohrn, P Rawal, C Luebbert, K Lehmkemper… - International Journal of …, 2021 - Elsevier
… Spray drying ASDs starts with preparing an API/polymer/solvent feed mixture, where API …
Thus, choosing appropriate inlet conditions for the spray dryer, at best saving or limiting a …
Thus, choosing appropriate inlet conditions for the spray dryer, at best saving or limiting a …
[HTML][HTML] Physical stability and release properties of lumefantrine amorphous solid dispersion granules prepared by a simple solvent evaporation approach
… Preparation of ASDs using these alternative processes will differ from conventional methods
due to the slow solvent … an aqueous environment during anti-solvent precipitation, and are …
due to the slow solvent … an aqueous environment during anti-solvent precipitation, and are …
Application of a three-fluid nozzle for the preparation of amorphous solid dispersions
C Corell, S Seyferth, D Fischer, HA Schiffter - Drying Technology, 2023 - Taylor & Francis
… ASDs with this setup is limited in either the choice of solvent, as polymer and API need to
be soluble in the same solvent, or the choice … be soluble in the same solvent as the drug. A …
be soluble in the same solvent, or the choice … be soluble in the same solvent as the drug. A …
Pharmaceutical methods for enhancing the dissolution of poorly water-soluble drugs
T Mahmood, RM Sarfraz, A Ismail, M Ali… - ASSAY and Drug …, 2023 - liebertpub.com
… reported for these ASD preparations. Enhanced solubility … select a suitable solvent using
various nonvolatile solvents. Subsequently, liquisolid preparations of ketoprofen were prepared …
various nonvolatile solvents. Subsequently, liquisolid preparations of ketoprofen were prepared …
[HTML][HTML] Continuous downstream processing of milled electrospun fibers to tablets monitored by near-infrared and Raman spectroscopy
… of electrospinning (eg less solvent, fast and gentle drying, low … spectral signs of the prepared
ASD were characteristics and not … to be suitable in all cases for variable selection, where the …
ASD were characteristics and not … to be suitable in all cases for variable selection, where the …
Prediction of phase behavior of spray-dried amorphous solid dispersions: Assessment of thermodynamic models, standard screening methods and a novel …
A Ousset, PF Chavez, J Meeus, F Robin, MA Schubert… - Pharmaceutics, 2018 - mdpi.com
… ASDs obtained by both solvent and solvent-free preparation … achieved by quench-cooled
ASD is particularly true for GFA … choice, DL, solvent/solvent-free preparation method, solvent …
ASD is particularly true for GFA … choice, DL, solvent/solvent-free preparation method, solvent …
[HTML][HTML] Co-amorphous solid dispersion systems of lacidipine-spironolactone with improved dissolution rate and enhanced physical stability
Z Wang, M Sun, T Liu, Z Gao, Q Ye, X Tan… - Asian Journal of …, 2019 - Elsevier
… -ASDs systems and to select the optimal molar ratio of LCDP and SPL for maintaining good
physical … system (1:6), due to the residual ethanol in the C-ASDs system prepared by solvent …
physical … system (1:6), due to the residual ethanol in the C-ASDs system prepared by solvent …