[HTML][HTML] … serotonin reuptake inhibitor-treatment does not show beneficial effects on cognition or amyloid burden in cognitively impaired and cognitively normal subjects

Y Bouter, C Bouter - Frontiers in Aging Neuroscience, 2022 - frontiersin.org
… (2011) first showed a serotonin-dependent reduction of Aβ levels in the brain interstitial fluid
(ISF) in APP/PS1 mice after short-term treatment with citalopram or fluoxetine. Furthermore, …

G-protein-coupled receptors in CNS: a potential therapeutic target for intervention in neurodegenerative disorders and associated cognitive deficits

S Azam, ME Haque, M Jakaria, SH Jo, IS Kim, DK Choi - Cells, 2020 - mdpi.com
… mGluR5 in the mouse (APPswe/PS1ΔE9) ameliorates cognitive … gyrus regulates synaptic
plasticity, learning, and memory. In … Similarly, a study involving chronic citalopram use (20 mg; …

First evidence of protective effects on stroke recovery and post-stroke depression induced by sortilin-derived peptides

M Pietri, A Djillani, J Mazella, M Borsotto… - …, 2019 - Elsevier
… of brain plasticity by mini-spadin could play a key role in its … -treated mice did not ameliorate
their performance during the … improve spatial memory in the Morris water maze (MWM) test in …

[HTML][HTML] The effect of melatonin and exercise on social isolation-related behavioral changes in aged rats

BS Alghamdi - Frontiers in Aging Neuroscience, 2022 - frontiersin.org
… effect on the experiment outcome from female rats. The rats were … In the current study, we
focused on spatial memory; the Y … measured using MWM escape latency exhibited amelioration

Personalizing the care and treatment of Alzheimer's disease: An overview

D Svob Strac, M Konjevod, M Sagud… - Pharmacogenomics …, 2021 - Taylor & Francis
… For example, the combination of memantine and citalopram … , synaptic plasticity, and behavioral
deficits in a mouse model … AM34c) ameliorated the cognitive function in SAMP8 mice by …

Zinc and central nervous system disorders

B Wang, T Fang, H Chen - Nutrients, 2023 - mdpi.com
Synaptic Zn 2+ is necessary for neural transmission, playing … + -enriched diets could impair
spatial memory in Tg2576 and … Chronic treatment with citalopram and fluoxetine, which are …

Pharmacological treatment of depression in Alzheimer's disease: a challenging task

T Cassano, S Calcagnini, A Carbone… - Frontiers in …, 2019 - frontiersin.org
… , and citalopram) and that chronic treatment with citalopram caused a 50% reduction Aβ
plaques in the cortex and hippocampus of a mouse … of Aβ levels in a mouse model of AD was …

Bioactive Compounds and Their Influence on Postnatal Neurogenesis

S Mattova, P Simko, N Urbanska, T Kiskova - International Journal of …, 2023 - mdpi.com
… to uncover strategies for enhancing brain plasticity. This review … Specifically, it ameliorated
CUMS-induced hippocampal … 2.5 mg/kg) and citalopram (an antidepressant drug belonging …

Diurnal effects of polypharmacy with high drug burden index on physical activities over 23 h differ with age and sex

T Tran, J Mach, G Gemikonakli, H Wu, H Allore… - Scientific reports, 2022 - nature.com
… In mouse models of Alzheimer’s disease, citalopram improves spatial learning in female
54 , but not in males 55 . Oxycodone can acutely increase exploratory behaviors in …

To be continued? Long-term treatment effects of antidepressant drug classes and individual antidepressants on the risk of developing dementia: a German Case …

C Bartels, M Belz, J Vogelgsang… - The Journal of …, 2020 - psychiatrist.com
… plaque burden in transgenic mouse models of AD and in … of citalopram—may be promoted
by increased brain amyloid-β … bipolar disorders, and subjects with bipolar disorders were …