… reduced absorption of allopurinol, cannot convert allopurinol to oxypurinol as … allopurinol
to oxypurinol should be saturable if XO is primarily responsible for the metabolism of allopurinol…

… Allopurinol and oxipurinol (oxypurinol) lower serum urate and urine uric acid levels.
Starting allopurinol at 100 mg/day and slowly titrating upward towards or above 300 mg/day …

… Previously, we described the effect of allopurinol and oxypurinol on hypoxanthine, xanthine,
and uric acid in neonates with HIE using a population PK-PD approach [16]. In that study, …

… The purine analog allopurinol is a substrate for XO. The main metabolite is oxypurinol—an
XO inhibitor and predominantly responsible for allopurinol’s therapeutic action. Febuxostat is …

… We speculate that the acute effects of allopurinol in the kidney might result from precipitation
of allopurinol or its less soluble metabolite oxypurinol [27], or alternatively of xanthine which …

… patients newly treated with allopurinol or febuxostat (baseline … renal disease with allopurinol
use and allopurinol dose vs. … Results: There were 31,465 new allopurinol or febuxostat …

… that allopurinol is a safe option in non-CKD patients. Oxypurinol, the major metabolite of
allopurinol, … Some studies have demonstrated an increased risk of allopurinol-induced adverse …

… And the pharmacokinetics results showed that allopurinol BOPT were able to provide a slow
release of allopurinol, and oxypurinol … In addition, studies of this report on pharmacokinetics …

… allopurinol), which does not allow for increased enzyme levels to occur. Also, the presence
of allopurinol or oxypurinol … there is no reported effect on CYP3A by allopurinol or oxypurinol. …

… ➢ Pharmacokinetics of lesinurad was not altered by allopurinol. Mild reduction in plasma
oxypurinol was observed in combination treatment with lesinurad and allopurinol; however, …