… In a chronic constriction injury model (CCI), tizanidine showed … were seen in the IT clonidine
compared with IT morphine or … Thus, in the monkey, results similar to the mouse are seen. …

… Significant differences between groups treated with tizanidine alone or in associaxion with …
protective effects of tizanidine and perhaps of other alphaadrenoceptor agonists (ie clonidine) …

… hind-paw licking when compared with saline-injected animals. … the antinociceptive effects
of clonidine in mice when using … MR: Inhibitory effects of clonidine and tizanidine on release of …

… involvement of α-adrenoceptors in the antinociceptive effects … dose–response curve and
compared to a theoretical additive … synergistic antinociception of carbamazepine–clonidine and …

… greater efficacy and reduced side-effects compared to clonidine (159). … Tizanidine, an <X2-adrenoceptor
agonist structurally … The role of alpha-adrenoceptor SUbtypes in sympaн thetic …

… α 2 -agonists, including clonidine and dexmedetomidine (18, 74). Compared with control
mice, α 2 -agonists were completely ineffective as an antinociceptive agent in the tail immersion …

… when tizanidine was combined with au NSAID as compared with … These inhibitory actions
of tizanidine and clonidine were … was shown to have an independent antinociceptive action10*…

… , and the relative potencies compared to epinephnne= 1. 0 … decreased the analgesiC effect
of dexmedetomidine(80 and … , had no effect on dexmedetornidine but augmented clonidine …

… The purpose of this study was to compare the synergistic anti-… antinociceptive effect of tizanidine
(3 mg/kg, po), tizanidine … that tizanidine has a similar anti-inflammatory action to clonidine…

… involved in the antiallodynic and antinociceptive effects of SNRIs in rodent models with
neuropathic pain; however, the involvement … When antinociceptive effects were compared in each …