… We compared normal B-lineage differentiation and in vivo leukemic cell states using single
cell RNA-sequencing (scRNA-seq) and several complementary genomics profiles. Based on …

… of myeloid differentiation) genes at various stages of B cell … cell fate reprogramming: B lymphoid
progenitors become T … of the highly diverse complementarity-determining region 3 (CDR3…

… of complement … B lymphoid transcription factors (E2A, EBF1, Pax5, and RUNX1), is
hypermethylated in the progenitor stage, and undergoes demethylation during B cell differentiation …

… The blockage at the early B lymphoid cell development … , where the disruption of basal
regulatory networks prevents the … of three modules (ig differentiation genetic core, communication …

… system requires appropriate regulation of dynamic transcription-factor networks that activate
lineage-specific gene expression and restrict the differentiation options of hematopoietic …

… differentiation is arrested in many B-ALL cases. Additional known or putative B-lymphoid
regulatory genes … Two recent complementary studies have provided important insights into the …

… interactions have been experimentally demonstrated to regulate the differentiation of a GMP
… scheme for hematopoiesis the regulation of B-lymphoid versus myeloid cell fate choice …

… well as differentiation signals. In this review, we first describe checkpoint mechanisms during
… to avoid autoimmunity and the emergence of B-lymphoid malignancies. In this review, we …

… regulation of B cell differentiation in mouse and human bone marrow, we measured the
expression of the major genes dictating B cell differentiation … the earliest B lymphoid progenitor …

… AF9 moiety of the fusion protein via an epigenetic mechanism that involves the recruitment of
5-… Ishibashi et al., “Complementary regulation of early B-lymphoid differentiation by genetic …