Growth factor independence 1 (Gfi1) as a regulator of lymphocyte development and activation
T Möröy, C Khandanpour - Seminars in immunology, 2011 - Elsevier
… distinct stages of early T- or B-lymphoid development and … mechanisms regarding regulation
of IL-7R signaling, Gfi1 controls Il-7R signaling in the early steps of pre T-cell differentiation, …
of IL-7R signaling, Gfi1 controls Il-7R signaling in the early steps of pre T-cell differentiation, …
Polycomb-group proteins in hematopoietic stem cell regulation and hematopoietic neoplasms
V Radulović, G de Haan, K Klauke - Leukemia, 2013 - nature.com
… epigenetic mechanisms that maintain the balance between self-renewal and differentiation.
… These Ezh2- and Ezh1-containing PRC2 complexes appear to have complementary …
… These Ezh2- and Ezh1-containing PRC2 complexes appear to have complementary …
[HTML][HTML] Heterochromatic genes undergo epigenetic changes and escape silencing in immunodeficiency, centromeric instability, facial anomalies (ICF) syndrome
ME Brun, E Lana, I Rivals, G Lefranc, P Sarda… - PLoS …, 2011 - journals.plos.org
… epigenetic changes might occur, ie at the chromatin level. Thus, to better understand gene
regulation … Genes located in the euchromatic flanking domain had either active or repressive …
regulation … Genes located in the euchromatic flanking domain had either active or repressive …
Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies
ARD Delbridge, S Grabow, A Strasser… - Nature Reviews Cancer, 2016 - nature.com
… Alterations of both anti-apoptotic and pro-apoptotic genes through genetic or epigenetic
mechanisms have been observed in cancer. a | Increased levels of anti-apoptotic BCL-2 family …
mechanisms have been observed in cancer. a | Increased levels of anti-apoptotic BCL-2 family …
Functional antagonism of the Polycomb-Group genes eed and Bmi1 in hemopoietic cell proliferation
J Lessard, A Schumacher… - Genes & …, 1999 - genesdev.cshlp.org
… genetic interaction between the two genes is cell-type specific as the presence of one or two
mutant alleles of eed trans-complements … myeloid and B-lymphoid differentiation pathways. (…
mutant alleles of eed trans-complements … myeloid and B-lymphoid differentiation pathways. (…
Aberrant ZNF423 impedes B cell differentiation and is linked to adverse outcome of ETV6-RUNX1 negative B precursor acute lymphoblastic leukemia
L Harder, G Eschenburg, A Zech… - Journal of Experimental …, 2013 - rupress.org
… A similar role for ZNF423 in normal B lymphoid development … the full complement of
intermediary stages of differentiation. … expressed B lymphoid development–related genes in B …
intermediary stages of differentiation. … expressed B lymphoid development–related genes in B …
Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia
CG Mullighan, S Goorha, I Radtke, CB Miller… - Nature, 2007 - nature.com
… the full complement of cooperating lesions and their distribution within the known genetic
subtypes … in genes that regulate B-lymphocyte differentiation in 40% of B-progenitor ALL cases. …
subtypes … in genes that regulate B-lymphocyte differentiation in 40% of B-progenitor ALL cases. …
[HTML][HTML] Current concepts in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia
KM Bernt, SP Hunger - Frontiers in oncology, 2014 - frontiersin.org
… level, and translate findings into complementary targeted approaches. Expanding targeted
… to B-cell leukemogenesis is a differentiation block in the B-lymphoid lineage at the pro- to …
… to B-cell leukemogenesis is a differentiation block in the B-lymphoid lineage at the pro- to …
[PDF][PDF] The Satb1 protein directs hematopoietic stem cell differentiation toward lymphoid lineages
Y Satoh, T Yokota, T Sudo, M Kondo, A Lai… - Immunity, 2013 - cell.com
… (D) The absolute numbers of total recovered cells and B-lymphoid cells in the MS5 coculture
(left … As a complementary experiment, we performed a set of microarray analyses comparing …
(left … As a complementary experiment, we performed a set of microarray analyses comparing …
[HTML][HTML] Human B lymphomas reveal their secrets through genetic mouse models
N Mossadegh-Keller, G Brisou, A Beyou… - Frontiers in …, 2021 - frontiersin.org
… incidence of other B-lymphoid neoplasms was observed (64). … cell differentiation genes,
particularly Blimp1 and Irf4 (99, 100). … and complementary in vivo studies (80, 108). The …
particularly Blimp1 and Irf4 (99, 100). … and complementary in vivo studies (80, 108). The …