… of mutations associated with most atovaquone-proguanil … Along with the key issue of
emergence and spreading of … three ratio reported for 135 isolates from West and Central Africa …

… is used therapeutically for treating Plasmodium falciparum malaria, … are children under five
years old in sub-Saharan Africa [ … confirmation of atovaquone-proguanil-resistant Plasmodium …

… target for antimalarial drug development. Here we report that … failures after atovaquone–proguanil
combination therapy (… To confirm the absence of an explanatory cyt-b mutation, the …

… vitro confirmation of resistance of Plasmodium falciparum isolate from … for mutations
related to atovaquone/proguanil resistance in … to west Africa. Am J Trop Med Hyg 2005, 72:407-409. …

… , including multidrug-resistant Plasmodium falciparum. The … subSaharan Africa, both
doxycycline and atovaquoneproguanil … Confirmation of emergence of mutations associated with …

… a high rate of resistance emergence intuitively offers greater … However, the metabolic impact
of resistance mutations to … that, unlike atovaquone/proguanil, parasites becoming resistant to …

… A total of 477 pre-treatment African isolates of P. falciparum … were no confirmed cases of
malaria in either arm of this study. … of atovaquone resistance to Plasmodium falciparum in vitro …

… resistance to emerge has been identified as K76T. Its importance was definitively confirmed
… Multiple origins and regional dispersal of resistant dhps in African Plasmodium falciparum …

… of artemisinin resistance has emerged in sub-Saharan Africa … Atovaquone-proguanil —
Atovaquone-proguanil interferes with two … for the treatment of Plasmodium falciparum, although it …

… Atovaquone-proguanil is highly effective in preventing Plasmodium falciparum malaria, is
well-… ovale, and as a “radical cure” in patients with confirmed infections [70]. The recommended …