… in 516 isolates from seven parasite populations in Africa, … In the present sample set, we
did not observe a mutation at … Ser, Cys or Asn was correlated to atovaquone resistance follo…

… , continued emergence and dissemination of drug-resistant … and dose-response analysis
confirmed a 90-fold increase in … mutations of the DEC-R line confer decoquinate resistance. First…

… rapid emergence of atovaquone-resistance mutations effectively … More recent studies described
later have confirmed and … use of the atovaquone–proguanil combination as antimalarials …

… It was also confirmed that high prevalence of the mutations at … of cytochrome b in
atovaquone-proguanil resistance in P. … in Plasmodium falciparum genes related to drug …

… Molecular evidence confirm that the clad formed by these … , when the human line and the
African great apes diverged, P. … In summary, gene amplification can give rise to new genes with …

… pathogenic for humans, Plasmodium falciparum, P. vivax, … Clinical trials confirmed safety;
however, a Phase II dose-… together with atovaquone/proguanil (NCT01442168) versus …

… are due to Plasmodium falciparum, the species most common in sub-Saharan Africa. (2) …
In vitro metabolism data confirm that the promoiety of ELQ-331 is cleaved to return ELQ-300 …

… in Africa, and must be considered when using this drug. … falciparum to atovaquone/proguanil
14 and underscores the … not be used in patients with a history of blood dyscrasias. …

… malaria caused by Plasmodium falciparum alone in 2002. … are antifolates, atovaquone-proguanil
affects the mitochondria … (98.5%), and bioassay confirmed high resistance to DDT and …

… Africa and confirms the findings from other areas of Africa … in the current study, children with
a history of illness >3 days were … studies indicate that multidrug resistance has emerged in P. …