[PDF][PDF] MOLECULAR MODELLING OF THE CANNABINOID RECEPTORS: STRUCTURE BASED DESIGN, SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF …

JLOOS EE - 2015 - core.ac.uk
… that CB1 receptors located in the brainstem region control the … Multiple sclerosis (MS) is
an autoimmune, inflammatoryreceptor, and the conformations ranked in order to provide a …

Advances in diagnostics and treatment of neurotoxicity after sports-related injuries

TA Gennarelli, SA Dambinova, JD Weissman - 2017 - books.rsc.org
autoimmune reaction with Ab formation leading to the risk of brain … to nanoparticles or
inserted into liposomes. To evade toxic side … through reversible inhibition of glutamate receptors, …

Carcinoid syndrome: preclinical models and future therapeutic strategies

G Vitale, S Carra, Y Alessi, F Campolo… - International Journal of …, 2023 - mdpi.com
… (VMAT1), metabotropic glutamate receptor 4, b1-adrenergic receptor, … inflammatory syndrome
in a patient with an atypical multisystem illness with CS as well as atopic and autoimmune

The role of the sigma subunit of Adaptor Protein-2, AP2σ2, in the regulation of calcium homeostasis

A Rogers - 2016 - ora.ox.ac.uk
Allosteric modulators of … Positive allosteric modulators of the CaSR comprising NPS R-568,
cinacalcet, AC- 265347, glutathione, and L-phenylalanine. (B) Negative allosteric modulators

Designing Immunotherapies for Cancer Treatment

Z Wan - 2021 - search.proquest.com
… a novel role of the metabotropic glutamate receptor-4 (GRM4) in … in immune modulation
was first described in an autoimmune … ), a Grm4-positive allosteric modulator, led to increased …

XIth International Symposium on Cholinergic Mechanisms-Function and Dysfunction & 2nd Misrahi Symposium on Neurobiology

I Silman… - 2002 - apps.dtic.mil
Send comments regarding this burden estimate or any other aspect of this collection of
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[PDF][PDF] β-Amyloid Therapeutic Strategies for Alzheimer's Disease

F Speroni - 2005 - researchgate.net
… (NMDA) receptor complex is a subtype of glutamate receptor … , controlled studies aimed at
reducing inflammation in the brain … is an allosteric modulation of -secretase activity (267-269), …

The pathophysiology and therapeutic potential of purinergic signalling

G Burnstock - Purinergic Signalling, 2017 - Springer
… increased in septic monocytes when compared with a control … new agonists or positive
allosteric modulators able to boost … receptors represent good targets to suppress inflammatory

Structure Elucidation, Signaling Mechanism and Structure-Based Lead Design of the Human Cannabinoid Receptor 2 (CB2)

C Xing - 2020 - search.proquest.com
modulators give us a better chance to design CB1 or CB2 selective drugs because most of
the … Although several CB1 and CB2 allosteric modulators have been developed, we are still in …

Impact of Juvenile Stress on Hippocampal Synaptic Plasticity and Memory in Adult Rats

R Raghuraman - 2019 - search.proquest.com
… altered levels in pro-inflammatory cytokines that are released … /ERK kinase Metabotropic
glutamate receptor Mammalian … (a positive allosteric modulator of AMPA receptors) resulted …