Structure Elucidation, Signaling Mechanism and Structure-Based Lead Design of the Human Cannabinoid Receptor 2 (CB2)

C Xing - 2020 - search.proquest.com
modulators give us a better chance to design CB1 or CB2 selective drugs because most of
the … Although several CB1 and CB2 allosteric modulators have been developed, we are still in …

Impact of Juvenile Stress on Hippocampal Synaptic Plasticity and Memory in Adult Rats

R Raghuraman - 2019 - search.proquest.com
… altered levels in pro-inflammatory cytokines that are released … /ERK kinase Metabotropic
glutamate receptor Mammalian … (a positive allosteric modulator of AMPA receptors) resulted …

Experimental treatments for retinitis pigmentosa in animal models: targeting insulin receptor, GSK-3 and Toll-like receptors

A Sánchez Cruz - 2021 - docta.ucm.es
… These results provide proof of concept of the therapeutic … In the same direction, the
administration of clodronate liposomes … of autoimmune diseases, cancer and inflammatory

Localization and characterization of binding sites for Ca2+ binding proteins and phosphatidylinositol phosphates on intracellular termini of TRP channels

K Boušová - 2016 - dspace.cuni.cz
… cell swelling may also act indirectly to activate TRPs through … binding proteins that use calcium
influx to control a variety of … ) and the freshly-formed liposomes were incubated with 8 mM …

The regulation of neutrophil migration in patients with sepsis: the complexity of the molecular mechanisms and their modulation in sepsis and the heterogeneity of …

Ø Bruserud, KA Mosevoll, Ø Bruserud, H Reikvam… - Cells, 2023 - mdpi.com
inflammation through effects on protease-activated receptors … , the modulation of fatty acid
saturation is important to control … membrane and for regulation of receptor-initiated signaling […

Interferon-gamma (IFNγ) inhibits adenosine A2A receptor function in hepatic stellate cells by downregulating expression of adenylyl cyclase in a STAT1-dependent …

ET Block - 2009 - search.proquest.com
… In the unlikely event that the author did not send a complete manuscript … -fibrotic but pro-inflammatory
cytokine, we examined its effect on A2A receptor-stimulated collagen production in …

[PDF][PDF] Young Neuroscientists (BraYn), Italy, 28–30 September 2022

G Ferrara - 2023 - researchgate.net
… to be associated with several autoimmune diseases including MS. … patients versus 38 healthy
controls using the Single Molecule … Here, we induced systemic inflammation in mice with a …

[PDF][PDF] BBA-Molecular Basis of Disease

T Bele, T Turk, I Krizaj - researchgate.net
positive allosteric modulators (PAMs), negative allosteric … to anti-inflammatory pathway, which
is regulated through α7 nAChR … observed between nAChRs and glutamate receptors [136]. …

Translating Innovative Technology to Patient Care

M Piquette-Miller - 2018 - journals.library.ualberta.ca
… We are involved in the science and technology of controlled delivery of drugs and … ,
professionals, and industry leaders in the area of controlled release – in the past, we have held …

Localization and Trafficking of CXCR4 and CXCR7

A İşbilir - 2022 - opus.bibliothek.uni-wuerzburg.de
… Class C GPCRs comprise the metabotropic glutamate receptors, … ) B receptors (GABABR),
a calcium sensing receptor (CaSR), … allosteric modulator, NAM) or active (positive allosteric