Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction

M Ayalew, H Le-Niculescu, DF Levey, N Jain… - Molecular …, 2012 - nature.com
convergent functional genomics (CFG) approach to identify and prioritize genes involved in
schizophrenia, by gene-level … genes identified by CFG can be used to generate a genetic risk …

Towards understanding the schizophrenia code: an expanded convergent functional genomics approach

H Le‐Niculescu, Y Balaraman, S Patel… - … of Medical Genetics …, 2007 - Wiley Online Library
gene expression as tools to tag genes that may have pathophysiological relevance. Changes
in gene … candidate gene generation and convergent functional genomics. However, not all …

Convergent functional genomics of psychiatric disorders

AB Niculescu - … Genetics Part B: Neuropsychiatric Genetics, 2013 - Wiley Online Library
… of a better understanding range from alleviating mental illness and … genetic and gene
expression studies, from humans and animal models, using Convergent Functional Genomics in …

[HTML][HTML] Identifying a series of candidate genes for mania and psychosis: a convergent functional genomics approach

AB NICULESCU III, DS SEGAL… - … genomics, 2000 - journals.physiology.org
… “convergent functional genomics.” We report here that the gene expression and linkage
results converge on a series of novel high-probability candidate genes for mania and psychosis. …

[HTML][HTML] Schizophrenia genomics: convergence on synaptic development, adult synaptic plasticity, or both?

J Hall, NJ Bray - Biological Psychiatry, 2022 - Elsevier
… exome sequencing analyses of schizophrenia, together with functional genomics data from
the pre- … , are currently limited by our incomplete understanding of gene function and do not …

Identification of blood biomarkers for psychosis using convergent functional genomics

SM Kurian, H Le-Niculescu, SD Patel, D Bertram… - Molecular …, 2011 - nature.com
schizophrenia and bipolar disorder reveals points of convergence between genetic and
functional genomic approaches. Am J Med Genet B Neuropsychiatr Genet 2005; 136: 12–25. …

Convergent functional genomics of genome‐wide association data for bipolar disorder: Comprehensive identification of candidate genes, pathways and mechanisms

H Le‐Niculescu, SD Patel, M Bhat… - … of Medical Genetics …, 2009 - Wiley Online Library
… approach, convergent functional genomics (CFG) [Niculescu et … gene association studies
with more SNPs tested per gene, … integrated those data with human postmortem brain gene

Functional genomics reveal gene regulatory mechanisms underlying schizophrenia risk

Y Huo, S Li, J Liu, X Li, XJ Luo - Nature communications, 2019 - nature.com
… in the reported loci confer schizophrenia susceptibility remains largely … gene regulatory
mechanisms underpinning schizophrenia risk through integrating data from functional genomics (…

Advancing a functional genomics for schizophrenia: psychopathological and cognitive phenotypes in mutants with gene disruption

BP Kirby, JL Waddington, CMP O'Tuathaigh - Brain research bulletin, 2010 - Elsevier
… phenotypes in mice mutant for such genes is based upon an evolving body of convergent
mutants, so as to indicate current standing in divining a functional genomics for schizophrenia. …

Functional analysis of schizophrenia genes using GeneAnalytics program and integrated databases

T Sundararajan, AM Manzardo, MG Butler - Gene, 2018 - Elsevier
… -based gene analysis program and integrated genomic databases to … schizophrenia in our
study adding to the relevance of this gene profile program in the study of genes and genetic