… A further analysis of these differences in the development of the cortico-efferent pathology
… From the results of this cross-sectional study, it could be assumed that the cortico-efferent …

… There is an ongoing debate whether primary lateral sclerosis (PLS) should be regarded
as an independent disease entity separate from amyotrophic lateral sclerosis (ALS) or as a …

… The stereotypical pathoanatomy in the brain on the one hand and the distinct clinical
phenotypes on the other hand, like also in primary lateral sclerosis or in the lower motor neuron …

… Across all diffusion metrics, the most significant changes were observed in the corticospinal
tracts and in the body of the corpus callosum. Thalamic white matter involvement was also …

… Neuroimaging has the potential to play an important role in the evaluation of novel … Amygdala
pathology in amyotrophic lateral sclerosis and primary lateral sclerosis. J Neurol Sci. 2020;…

… to appraise descending motor tract degeneration and bulbar lower motor neuron involvement.
… The sponsors of this study had no direct role in the design, analyses, presentation of this …

… tract involvement for more than 2 years after the onset of symptoms. Sparing of central
motor pathways was confirmed with magnetic transcranial motor evoked potential analysis. …

… Given the lack of lower motor neuron involvement in PLS, we hypothesise that focal … Reduced
primary motor cortex thickness and altered corticospinal tract diffusion metrics have been …

… process underlying amyotrophic lateral sclerosis (ALS) … differ from the ‘classical’ involvement
of the upper and the lower … , the diagnostic criteria for primary lateral sclerosis as a slowly …

… Primary lateral sclerosis (PLS) has been traditionally viewed … sub-phenotype within the
amyotrophic lateral sclerosis (ALS) … in vivo and has underscored the role of neuro-inflammation, …