[HTML][HTML] Current concepts in tumour-derived organoids
RJ Porter, GI Murray, MH McLean - British journal of cancer, 2020 - nature.com
… specific therapy by organoid culture using tumour-derived organoids. c Future applications
of organoids may involve a more direct role in treatment, such as using organoids to generate …
of organoids may involve a more direct role in treatment, such as using organoids to generate …
[HTML][HTML] Clinical translation of patient-derived tumour organoids-bottlenecks and strategies
… the current research. Researchers are engrossed on the discovery and refinement of techniques
in growing different types of organoids and … While the general premise is that organoid …
in growing different types of organoids and … While the general premise is that organoid …
Challenges, applications and future directions of precision medicine in prostate cancer–the role of organoids and patient‐derived xenografts
A Joshi, MJ Roberts, S Alinezhad… - BJU …, 2020 - Wiley Online Library
… The main models used include tumour-derived two-dimensional (2D) cell culture, PDXs
and more recently three-dimensional (3D) ‘organoid’ culture. Each technique has benefits, as …
and more recently three-dimensional (3D) ‘organoid’ culture. Each technique has benefits, as …
[HTML][HTML] Patient-derived explants, xenografts and organoids: 3-dimensional patient-relevant pre-clinical models in endometrial cancer
A Collins, GJ Miles, J Wood, M MacFarlane… - Gynecologic …, 2020 - Elsevier
… cancer include spheroids, patient-derived organoids, microfluidic systems, patient-… present
a review of available 3D modelling systems in endometrial cancers, highlighting their current …
a review of available 3D modelling systems in endometrial cancers, highlighting their current …
[HTML][HTML] Patient-derived tumor organoids: a new avenue for preclinical research and precision medicine in oncology
L Thorel, M Perréard, R Florent, J Divoux… - … & Molecular Medicine, 2024 - nature.com
… reverse the polarity (apical-out polarity) of cystic organoids grown in ECM 37 or to establish
patient-derived glioblastoma organoids 38 . In this instance, glioblastoma samples were cut …
patient-derived glioblastoma organoids 38 . In this instance, glioblastoma samples were cut …
[HTML][HTML] Current and future perspectives of the use of organoids in radiobiology
PW Nagle, RP Coppes - Cells, 2020 - mdpi.com
… Interestingly, BCN057 did not have a radiomitigative effect in tumour-derived organoids
with these findings again mimicking in vivo findings. The same group also investigated the …
with these findings again mimicking in vivo findings. The same group also investigated the …
Organoids in cancer research
J Drost, H Clevers - Nature Reviews Cancer, 2018 - nature.com
… The receptor status of the parental tumour was lost in only a small number of organoid
cases, yet this highlights the need to adequately characterize tumour-derived organoids before …
cases, yet this highlights the need to adequately characterize tumour-derived organoids before …
[HTML][HTML] Advances towards the use of gastrointestinal tumor patient-derived organoids as a therapeutic decision-making tool
J Obreque, L Vergara-Gómez, N Venegas, H Weber… - Biological Research, 2023 - Springer
… Fortunately, the emergence of patient-derived organoid (PDOs) culture has enabled the ex
… (GI) tumors, herein we present the state-of-the-art and the current methodology of PDOs. We …
… (GI) tumors, herein we present the state-of-the-art and the current methodology of PDOs. We …
[HTML][HTML] Organoids as an enabler of precision Immuno-oncology
… oxygen supply to the cells and preserves the organoids for 30–60 days (Figure 1a). ALI
culture has enabled non-tumour and tumour-derived tissue samples to be cultured with native …
culture has enabled non-tumour and tumour-derived tissue samples to be cultured with native …
[HTML][HTML] Modelling immune cytotoxicity for cholangiocarcinoma with tumour-derived organoids and effector T cells
G Zhou, R Lieshout, GS van Tienderen… - British journal of …, 2022 - nature.com
… Therefore, the aim of the current study is to establish and optimise an in vitro 3D co-…
organoids with PBMCs and purified T cells and to study growth inhibition and induction of organoid …
organoids with PBMCs and purified T cells and to study growth inhibition and induction of organoid …