… for amiodarone and desethylamiodarone in lung amounts to … are the ciliated bronchial
epithelial cells, the alveolar … because the mechanism of cytotoxic action differs. However, the time …

… cells, secondary to the inhibition of lysosomal phospholipase activity induced by AD and
its major metabolite, desethylamiodarone … accumulation in ADinduced cytotoxic injury (steatosis, …

… The major active metabolite of amiodarone, desethylamiodarone (DEA… had shown amiodarone
to be cytotoxic to FRTL-5 thyroid cells; … cytotoxic effect of amiodarone. When intrathyroidal …

… Therefore, we recommend that amiodarone should be taken with meals. Amiodarone is
metabolized in the liver to desethylamiodarone [5]. During loading, it goes through three phases …

… is destructive thyroiditis caused by amiodarone, desethylamiodarone as its main metabolite,
… cell lysis11,49. These results support the fact that amiodarone achieves most of its cytotoxic …

… Sections in the lung of rats belonging to amiodarone group demonstrated small bronchioles
with partial obliteration of the lumen by shed epithelial cells and cellular infiltration in the …

… confounded by open-label bolus amiodarone injections given by study investigators. There
was, however, a trend toward a relationship between intended amiodarone dose and VT/VF …

… Amiodarone hydrochloride and N-desethylamiodarone (DEA), the major metabolite of …
Amiodarone hydrochloride cytotoxicity was less obvious when the cells were seeded at higher cell …

… and rat alveolar epithelial cells in vitro. Am J Physiol, 278, 1039-44 … Effects of vitamin E on
cytotoxicity of amiodarone and desethylamiodarone in isolated hamster lung cells. Toxicology, …

… Studies of another inducer of AEC apoptosis, the antiarrhythmic agent amiodarone, also
showed that antagonists of ANG production or receptor interaction could prevent apoptosis of …