… rabbit lung (pulmonary edema), and was not cytotoxic to human … micrograph of an alveolar
epithelial cell from the control … photolysis of amiodarone and desethylamiodarone. Photochem …

… Other potential mechanisms of amiodarone toxicity are: direct cytotoxicity, the … reduce
amiodarone- and desethylamiodarone-induced lysosomal phospholipidosis in cultured human skin …

… cells, secondary to the inhibition of lysosomal phospholipase activity induced by AD and
its major metabolite, desethylamiodarone … accumulation in ADinduced cytotoxic injury (steatosis, …

… Another important action of amiodarone and its metabolites is a direct cytotoxic effect on the
… in humans and animals,16 most studies suggest that it is unlikely that amiodarone therapy …

… amiodarone metabolism consists in dealkylation, which leads to the formation of
desethylamiodarone … The excess iodine released by the drug may contribute to the cytotoxicity …

… by the accumulation of amiodarone and its metabolite, desethylamiodarone, in the tissues
of the lung. This accumulation leads to direct cytotoxic damage and indirect immunologic …

… drugs (amiodarone) which trap the drug in the cells by … The main pharmacological
characteristics of cytotoxic drugs in … It begins as a small ulcer due to killing of some skin cells at …

… metabolite being N-desethylamiodarone (MDEA) … amiodarone induces the formation of
vacuoles and inclusion bodies in blood leukocytes, cells of the corneal epithelium, skin cells…

… owing to the cytotoxic effect of amiodarone on thyroidal follicular cells. … ing to the main active
metabolite, desethylamiodarone. Most effects are … effects on follicular epithelial cells. Thyroid …

… that amiodarone application has a reducing effect on selenium toxicity. This was because
amiodarone … and necrosis of some tubular epithelial cells. Bowman capsule shrinkage was …