… in this article are part of a treatment efficacy study that compared the sulfadoxine–pyrimethamine
(SP) … Unfortunately, our isolates did not include a genotype mutant at both 436 and 437 …

… Plasmodium falciparum dihydropteroate synthase (Pfdhps) and … Clinical trials to investigate
the efficacy of IPT-SP are much … Pyrimethamine binds far more strongly to the parasite DHFR …

… be incorporated with ongoing in vivo efficacy monitoring in areas … falciparum isolates
from Thies, as the increase in the number … Dhfr and dhps genotype and sulfadoxine–pyrimethamine …

… -108, which is associated with cycloguanil resistance [28–30]. … of SP treatment efficacy in
Gabon. These findings suggest … Treatment during infancy with sulfadoxine-pyrimethamine (…

… falciparum genotype was present in 64% of the samples. We … in the DHFR gene, and have
been associated with in vitro … to P/S in these Gabonese areas where a low efficacy of P/S was …

… genotype and chemosensitivity to pyrimethamine. For the … associated with sulfadoxine-pyrimethamine
(SP) treatment failure … vitro susceptibility of Gabonese wild isolates of Plasmodium …

… and sulfadoxine/pyrimethamine activity against parasite … To evaluate SP efficacy seven
years after Malawi replaced … between pyrimethamine and cycloguanil activity in vitro and …

… DHFR and DHPS genotypes of Plasmodium falciparum … of pyrimethamine and
cycloguanil, but not with sulfadoxine–pyrimethamine treatment efficacy …

… falciparum dihydrofolate reductase [Pfdhfr], respectively [5]. … resistance are widespread, SP
plus AQ remain efficacious in … preventive treatment [IPTi] with SP alone in infants in Gabon, …

… intermittent preventive treatment with sulfadoxine-pyrimethamine (… the partial efficacy of
two SP doses to clear these isolates. A … to pyrimethamine in Plasmodium falciparum malaria …