[HTML][HTML] Different In Vitro Drug Susceptibility Profile of Plasmodium falciparum Isolates from Two Adjacent Areas of Northeast Myanmar and Molecular Markers for …
M Duan, Y Bai, S Deng, Y Ruan, W Zeng, X Li… - Tropical Medicine and …, 2022 - mdpi.com
… to chloroquine and pyrimethamine but relatively sensitive to … and used for in vitro drug
assay and genotyping [13]. Frozen … first ACT introduced, but its efficacy steadily declined in the …
assay and genotyping [13]. Frozen … first ACT introduced, but its efficacy steadily declined in the …
Plasmodium falciparum in Kenya: high prevalence of drug-resistance-associated polymorphisms in hospital admissions with severe malaria in an epidemic area
SA Omar, IS Adagu, DW Gump, NP Ndaru… - Annals of Tropical …, 2001 - Taylor & Francis
… (sulfadoxine-pyrimethamine or amodiaquine) drug treatments. … There is clearly an urgent
need to explore the use and efficacy … cycloguanil and pyrimethamine in Plasmodium falciparum …
need to explore the use and efficacy … cycloguanil and pyrimethamine in Plasmodium falciparum …
[HTML][HTML] … with sulfadoxine resistance among Plasmodium falciparum clinical isolates from Iran, three years after the introduction of sulfadoxine–pyrimethamine
S Zakeri, MS Farahani, M Afsharpad, M Salehi… - International Journal of …, 2010 - Elsevier
… therefore the inadequate efficacy of treatment with the … vivo selection for a specific genotype
of dihydropteroate synthetase of Plasmodium falciparum by pyrimethamine–sulfadoxine but …
of dihydropteroate synthetase of Plasmodium falciparum by pyrimethamine–sulfadoxine but …
Withdrawing antimalarial drugs: impact on parasite resistance and implications for malaria treatment policies
MK Laufer, CV Plowe - Drug Resistance Updates, 2004 - Elsevier
… In one province in Gabon, in vitro chloroquine resistance … the in vivo efficacy of
sulfadoxine–pyrimethamine and chloroquine. … Pyrimethamine inhibits DHFR and sulfadoxine …
sulfadoxine–pyrimethamine and chloroquine. … Pyrimethamine inhibits DHFR and sulfadoxine …
… drugs resistance in Plasmodium falciparum isolates seven years after the adoption of sulfadoxine–pyrimethamine in combination with artesunate as first-line treatment …
M Rouhani, S Zakeri, S Pirahmadi, A Raeisi… - Infection, Genetics and …, 2015 - Elsevier
… in dhfr and dhps genes of Plasmodium falciparum isolates (n = … pure form with wild-type
genotype at positions N51 and I164. … treatment in Iran, this drug remains efficacious for treatment …
genotype at positions N51 and I164. … treatment in Iran, this drug remains efficacious for treatment …
Drug uptake, sensitivity, interaction studies and resistance associated mutations in Plasmodium falciparum
QL Fivelman - 2003 - researchonline.lshtm.ac.uk
… in the atovaquoneresistant NGATVOI isolate. While the … pyrimethamine seen in vitro is
supported by observations in … of the mean SP sulfadoxine/pyrimethamine combination (Fansidar®) …
supported by observations in … of the mean SP sulfadoxine/pyrimethamine combination (Fansidar®) …
[HTML][HTML] … review and meta-analysis of evidence for correlation between molecular markers of parasite resistance and treatment outcome in falciparum malaria
S Picot, P Olliaro, F de Monbrison, AL Bienvenu… - Malaria journal, 2009 - Springer
… (CQ) and sulphadoxine/pyrimethamine (SP) has rendered … Efficacy data could not be
correlated with parasite genotype … value of therapeutic failure with Sulfadoxine-pyrimethamine. …
correlated with parasite genotype … value of therapeutic failure with Sulfadoxine-pyrimethamine. …
Analysis of immune responses, genetic polymorphism and prevalence of molecular markers for drug resistance in Plasmodium falciparum in different endemic areas …
G Mlambo - 2006 - search.proquest.com
… was further analyzed by genotyping parasite DNA at the MSP-1… to chloroquine and
sulfadoxine/pyrimethamine were examined … sound and have shown some effectiveness, they may …
sulfadoxine/pyrimethamine were examined … sound and have shown some effectiveness, they may …
Antifolates: pyrimethamine, proguanil, sulphadoxine and dapsone
A Nzila - Treatment and Prevention of Malaria: Antimalarial Drug …, 2012 - Springer
… for the in vivo efficacy of Malarone ® but in areas of high … pyrimethamine are also resistant
to cycloguanil, and this cross resistance is the result of the selection of point mutations in DHFR…
to cycloguanil, and this cross resistance is the result of the selection of point mutations in DHFR…
[HTML][HTML] Malaria chemoprevention and drug resistance: a review of the literature and policy implications
CV Plowe - Malaria Journal, 2022 - Springer
… Pyrimethamine and other antifolates such as proguanil (via its metabolite cycloguanil) and
trimethoprim target P… those that rely on the antifolate drug sulfadoxine-pyrimethamine (SP). In …
trimethoprim target P… those that rely on the antifolate drug sulfadoxine-pyrimethamine (SP). In …