… further efforts to elucidate epigenetic alterations in cancer, and to subsequently develop new
epigenetic therapies. This review delineates the latest cancer epigenetic models, the recent …

… to extend our understanding of DNA methylation and its implication in several diseases. The
… field for DNMT inhibition. However, efficient and potent targeting of DNA methylation in cells …

… (DNMTs) to specific genomic loci to promote DNA methylation [19,20,21]. On the … DNA
methylation and histone modification machinery critical for maintaining the cellular epigenetic …

… role of human DNA methyltransferases (DNMTs) in cancer as well as the therapeutic potential
and challenge of inhibiting … Epigenetic therapy may reverse either silenced or repressed …

… DNA methyltransferase (DNMT) inhibitors represent a promising class of … , DNA methylation
is one of the most extensively characterized epigenetic modifications and its biological role is …

… , and it offers a target for the treatment of malignancy [2, 3]. In this review, methylation, its
role in cancer and the therapeutic agents that affect methylation will be described. …

… This review summarizes the main epigenetic mechanisms involved in cancer development,
with special focus on DNA methyltransferase enzymes and hypermethylation of tumor …

… We review emerging epigenetic targets in cancer and present recent models of … epigenetic
therapies. Significance: The use of DNA methyltransferase and histone deacetylase inhibitors …

… scaffolds, herein, we report five new inhibitors of DNMT1 with distinct chemical scaffolds. Two
… inhibitor (HDAC), another major epigenetic target, and could be used as a dual epigenetic …

… Epigenetic modifications, including DNA methylation and demethylation and histone …
Hence, epigenetic therapy has emerged as a rapidly advancing field of cancer research. A …