… of such treatment. Identification of aberrations of DNA methylation in cancer cells is a new
field of … We believe that epigenetic cancer diagnostic and therapy will be achieved in the next …

… of DNA methylation by DNMTs and specifically introduces this process in the context of tumor
… Similarly, Vendetti et al. proposed epigenetic treatments that target DNMTs and HDACs in …

… examined for their anti-cancer or therapeutic effects on neurological diseases. Three main
epigenetic treatments are in a reliable consideration: DNMT and HDAC inhibitors and miRNA-…

… Figure 2 A model for enhanced therapeutic efficacy by combining epigenetic therapy with
other … Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines. …

… DNA methyltransferase inhibitors have been approved as first-generation epigenetic inhibitors
for cancer therapy… knowing the status of DNA methylation as with DNA epigenetic mark, 5-…

… and drawbacks of nucleosidic DNA methylation inhibitors, which will assist … therapeutic
efficacy of these drugs and circumvent the challenges in the path of successful epigenetic therapy…

… Epigenetic therapy in cancer: molecular background and clinical development of histone
deacetylase and DNA methyltransferase inhibitors. IDrugs., 2007, 10, 557-561. [101] Kassis, ES…

… for cancer therapy. In this review, at first, we have an overview of the methylation alteration in
cancers, … about the regulation of DNA methylation regulators by epi-miRNAs in cancer cells. …

… DNA methyltransferases (DNMTs), their biological roles, their mechanisms of action and their
role in cancer… The description of assays for detecting DNMT inhibitors (DNMTi) follows. The …

… epigenetic aberrations during malignant transformation and explains how epidrugs target DNA
methylation, … to tumorigenesis (62); this poses a significant obstacle in epigenetic therapy. …