… epigenetic agents were DNA methyltransferase inhibitors; these were followed by histone
deacetylase inhibitors (… onstrated that epigenetic therapy with a DNMT inhibitor induced such …

… To confirm the specificity of the DNA methyltransferase inhibition by RG108, we also …
inhibitory activity. Molecular modeling suggested a critical role of the carboxyl group of RG108 in its …

… In addition, DNA methylation is an important regulator of … epigenetic therapeutic targets
currently under evaluation in AML: the lysine demethylase LSD1, the protein methyltransferases …

… (2009) Phase I study of MG98, an oligonucleotide antisense inhibitor of human DNA
methyltransferase 1, given as a 7-day infusion in patients with advanced solid tumors. Clin Cancer …

… such as enhancer of zeste homolog 2 (EZH2) and DNA methyltransferases such as DNA
methyltransferase 3α (DNMT3A). Chromatin modifications are highly dynamic and are readily …

… A number of DNA methylation inhibitors have been developed and can be classified into …
proteins involved in the regulation of gene expression, epigenetic treatment is appearing as …

… DNA methylation inhibitors activate not only abnormally silenced genes, but also … epigenetic
therapies and other cancer therapeutics. We also discuss existing challenges and emerging …

… epigenetics drugs work well alone in treating cancer, combinations of DNA methylation
and histone deacetylation inhibitors … in epigenetic therapy of cancer and its implications in …

… epigenetic state. The success of DNA methyltransferase and histone deacetylase inhibitors
… for the use of therapies intended to target the epigenome in the treatment of hematological …

… therapy was provided by Juergens et al. in lung cancer. They have proved that DNA methylation
inhibitors in … genes which upregulate significantly by epigenetic therapy. This drug also …