… -deficient O-glycans in its hinge region (galactose-deficient IgA1… This scenario is further
supported by the results of experiments … that are responsible for promoting the migration of these …

… These experiments show that defective oral tolerance, by permitting persistence ofIgG …
promotes nephritis, complement-fixing IgG and IgM co-deposits are critical for nephritogenesis in …

… induction of a defective mucosal tolerance [17]. A disrupted … In a pilot experiment, we reported
that mice fed with standard … a possible role of oral tolerance breakdown in various immune-…

… The hallmark of IgA nephropathy (IgAN) is macroscopic hematuria coinciding with, or …
The role of mucosal pathogens has been proven in different experimental models. Mucosal (or …

… of renal deposition of IgA and IgG-IC [28] through a defect of the complement-… oral tolerance
promotes nephritogenesis in experimental IgA nephropathy induced by oral immunization. .1 …

… of experimental IgA nephropathy. Lab Invest 57:269—276, 1987 … SN: Defective oral tolerance
promotes nephritogenesis in experimental IgA nephropathy induced by oral immunization, …

… , but only after induction of a defective mucosal tolerance [24, … a gluten-induced experimental
IgA glomerulopathy. Moreover… antigens and breakdown of oral tolerance. In other studies, a …

… from IgAN patients are enriched with these galactose-deficient … demonstrated; both in vitro
and in vivo experiments have … Although the key feature of nephritogenic IgA in IgAN is that …

… with IgA nephropathy are enriched for galactose-deficient IgA1 … These experimental
approaches demonstrate the key roles … in the formation of nephritogenic immune complexes. …

… Moreover, nephritogenic IgA and its related immune … -specific IgA has been investigated
with some experimental models … in autoimmune states, inducing a defect in the regulation of B…